Diarylethylene metallocene derivatives, their processes of prepa

Details Diarylethylene metallocene derivatives, their processes of prepa Diarylethylene metallocene derivatives, their processes of prepa

1997-08-11

1999-01-26

Nazario-Gonzalez, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514492, 514501, 514502, 544 64, 546 11, 548402, 556 43, 556 53, 556 58, 556143, 556144, 556145, 556136, A61K 31555, C07F 1700

Patent

active

058639110

ABSTRACT:
Diarylethylene metallocene derivatives, processes for preparing the same and pharmaceutical compositions which contain the derivatives are disclosed. The compounds of the invention can exhibit anti-tumor activity, and can be particularly useful in the treatment of estrogen-dependent cancers.

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Philip R. Kym et al., "Molecular Structures, Conformational Analysis, and Estrogen Receptor Ligands: LY117018 and Aryl Azide Photoaffinity Labeling Analogs", J. Med. Chem., 1993, vol. 36, No. 24, pp. 3910-3922.
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Douglas M. Wolf et al., "Drug Resistance to Tamoxifen During Breast Cancer Therapy", Breast Cancer Research and Treatment, 1993, 27, pp. 27-40.

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