Diarylamine-containing compounds and compositions, and their...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C544S330000

Reexamination Certificate

active

07638523

ABSTRACT:
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

REFERENCES:
patent: 2003/0191312 (2003-10-01), Ding et al.
patent: 2004/0102453 (2004-05-01), Buerger et al.
Biegon, A., “Effects of Steroid Hormones on the Serotonergic System,” Ann. NY Acad. Sci. 600:427-431 (1990).
Carroll, B.J. et al., “A Specific Laboratory Test for the Diagnosis of Melancholia,” Arch. Gen. Psychiat. 38:15-22 (1981).
CAS Search, Jun. 7, 2005.
Fedorak et al., “A novel, colon-specific steroid prodrug enhances sodium chloride absorption in rat colitis,” Am. J. Physiol. 269:G210-G218 (1995).
Hochhaus et al., “A Selective HPLC/RIA for Dexamethasone and its Prodrug Dexamethasone-21-sulphobenzoate Sodium in Biological Fluids,” Biomed. Chrom. 6:283-286 (1992).
Kapur, S. et al., “Role of the Dopaminergic System in Depression,” Biol. Psychiat. 32:1-17 (1992).
Larsen, J. et al., “Prodrug forms for the sulfonamide group. II. Water-soluble amino acid derivatives of N-methylsulfonamides as possible prodrugs,” Int. J. Pharmaceutics 47:103-110 (1988).
Larsen, J. and Bundgaard, H., “Prodrug forms for the sulfonamide group. I. Evaluation of N-acyl derivatives, N-sulfonylamidines, N-sulfonylsulfilimines and sulfonylureas as possible prodrug derivatives,” Int. J. Pharmaceutics 37:87-95 (1987).
Lloyd, K.G. et al., “The Gabaergic Hypothesis of Depression,” Prog. Neuro-Psycopharmacol. Biol. Psychiat. 13:341-351(1989).
McLeod et al., A Glucocorticoid Prodrug Facilitates Normal Mucosal Function in Rat Colitis Without Adrenal Suppression,: Gastroenterol. 106:405-413 (1994).
Munemura, M. et al., “Chronis Estrogen Treatment Promotes a Functional Uncoupling of the D2Dopamine Receptor in Rat Anterior Pituitary Gland,” Endocrinology 124:346-355 (1989).
Pinder, R.M. et al., “Third-Generation Antidepressants,” Med. Res. Rev. 13:259-325 (1993).
Rasmussen, K. and Aghajanian, G.K., “Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2antagonists,” Brain Res. 385:395-400 (1986).
Roy, E.J. et al., “Estradiol in the Striatum: Effects on Behavior and Dopamine Receptors but no Evidence for Membrane Steroid Receptors,” Brain. Res. Bull. 25:221-227 (1990).
Saulnier et al., “An Efficient Method for the Synthesis of Guanidino Prodrugs,” Bioorganic and Medicinal Chemistry Letters 4:1985-1990 (1994).
Shildkraut, J. et al., “The Catecholamine Hypothesis of Affective Disorders: A Review of Supporting Evidence,” Am. J. Psychiat. 12:509-522 (1965).
Siever, L.J. and Davis, K.L., “Overview: Toward a Dysregulatio Hypothesis of Depression,” Am. J. Psychiat. 142:1017-1031 (1985).
Sinkula, A.A. and Yalkowsky, S.H., “Rationale for Design of Biologically Reversible Drug Derivatives: Prodrugs,” J. Pharm. Sci. 64:181-210 (1975).
Sugrue, M.F. et al., “Current Concepts on the Mechanisms of Action of Antidepressant Drugs,” Pharmacol. Ther. 13:219-247 (1981).
Sulser,F. et al., “Commentary. Mode of Action of Antidepressant Drugs,” Biochem. Pharmacol. 27:257-261 (1978).
Mol, C.D. et al., “Structure of a c-Kit Product Complex Reveals the Basis for Kinase Transactivation,” J. Biol. Chem. 278(34):31461-31464 (2003).
Zhang, Z. et al., “Crystal structure of human stem cell factor: Implication for stem cell factor receptor dimerization and activation,” PNAS 97(14):7732-7737 (2000).
PCT/US06/37820 Search Report dated Sep. 5, 2007.
Kitamura et al., Cell. Mol. Life Sci. 61:2924-2931 (2004).
Cecil Textbook of Medicine, eds. Bennet, J.C. and Plum, F., 20thed. vol. 1, pp. 1004-1010, 1996.
Wolft, Manfred E., “Burger's Medicinal Chemistry,” 5thed., Part 1, John Wiley & Sons, 1995, pp. 975-977.
Banker, G. S. et al., “Modern Pharmaceutics,” 3rd ed., Marcel Dekker, NY, 1996, pp. 451 and 596.
West, A.R., “Solid State Chemistry and its Applications,” Wiley, NY 1988, pp. 358 and 365.
Vippagunta et al., Advanced Drug Delivery Reviews 48:3-26 (2001).

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