Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-03-03
1989-03-07
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514372, 514374, 514378, 514400, 514406, 514427, 514438, 514461, 514471, 548204, 548214, 548236, 548247, 548342, 548378, 548561, 548562, 549 74, 549 75, 549 78, 549492, 549495, 549498, A61K 3140, A61K 31415, A61K 3142, A61K 31425
Patent
active
048107166
ABSTRACT:
The present invention is novel diarylalkanoids having activity as lipoxygenase inhibitors, novel pharmaceutical compositions therefor, and novel methods of use in treating asthma, allergies, cardiovascular diseases, migraines, psoriasis and immunoinflammatory diseases for diarylalkanoids. The compounds of this invention are also useful as cytoprotective agents.
REFERENCES:
Lavrushin et al, Chemical Abstracts, vol. 76 (1972) 58463p.
Mann et al, Chemical Abstracts, vol. 104 (1986) 207078t.
Itokawa, H. et al., "Synthesis of Diarylheptanoids and Assessment of Their Pungency" Chem. Pharm. Bull., 31, 2491 (1983).
"A Pungent Principle for Alpinia Oxyphylla Phytochemistry," 21, 241 (1982).
Itokawa, H. et al., "Two New Diarylpehtanoids from Alpinia Offcinarum Hance", Chem. Pharm. Bull. 29(8) 2383-2385 (1981).
Rao, et al. "Antiinflammatory Activity of Curcumin Analogues", Indian J. Med. Res., 75 574-578 (Apr. 1982).
Pabon, "A Synthesis of Curcumin and Related Compounds" Recueil, 83 379-386 (1984).
Connor David T.
Flynn Daniel L.
Raymond Richard L.
Thierstein Joan
Warner-Lambert & Company
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