Diaryl-substituted five-membered heterocycle derivative

Details Diaryl-substituted five-membered heterocycle derivative Diaryl-substituted five-membered heterocycle derivative

2011-03-08

2011-03-08

Chandrakumar, Nizal S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S181000, C548S255000

Reexamination Certificate

active

07902369

ABSTRACT:
The present invention provides the compounds represented by formula (I):(I)or pharmaceutical salts thereof, wherein:X1represents oxygen atoms and the like, X2represents nitrogen atoms and the like, X3represents nitrogen atoms and the like, X4represents nitrogen atoms and the like, R1represents formula (II-1):wherein X5represents sulfur atoms and the like, A1represents carbon atoms and the like, A2represents nitrogen atoms and the like and A ring represents phenyl group and the like,having mGluR1 inhibiting effect, and being usefull for preventing or treating convulsion, acute pain, inflammatory pain, chronic pain, brain disorder such as cerebral infarction or transient ischemick attack, psychotic disorder such as schizophrenia, anxiety, drug dependence, Parkinson's disease, or gastrointestinal disorder.

REFERENCES:
patent: 6399641 (2002-06-01), Jolidon et al.
patent: 6969730 (2005-11-01), Cowart et al.
patent: 7105548 (2006-09-01), Cosford et al.
patent: 7417053 (2008-08-01), Unoki et al.
patent: 7538138 (2009-05-01), Cowart et al.
patent: 2005/0256118 (2005-11-01), Altenbach et al.
patent: 2003146990 (2003-05-01), None
patent: WO 03051315 (2003-06-01), None
Eistert et al. STN Abstract Document No. 73:14768, Justus Liebigs Annalen der Chemie (1970), 734, 56-69.
L'abbe et al. STN Abstract Document No. 122:290182 Bulletin des Societes Chimiques Beiges (1994), 103(7-8), 321-7.
International Search Report for JP PCT/JP2005/004379, dated May 24, 2005.
EP Search Report for EP JP PCT/JP2005/004379, dated Jun. 12, 2009.
International Preliminary Report on Patentability for JP PCT/JP2005/004379, Dec. 6, 2009.

Affiliated with

Also associated with

Rating

Diaryl-substituted five-membered heterocycle derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaryl-substituted five-membered heterocycle derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaryl-substituted five-membered heterocycle derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2719201