Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1988-03-14
1989-07-04
Gray, Bruce
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514605, 514640, 514646, 514647, 514676, 514684, 514708, 514709, 514710, 514712, 514713, 514716, 514719, 564 79, 564 83, 564 95, 564 99, 564256, 564265, 564307, 564440, 564441, 564442, 564443, 568 29, 568 30, 568 31, 568 33, 568 36, 568 37, 568 43, 568 44, 568 49, 568 62, 568306, 568303, 568644, 568645, 568646, A61K 3118, C07C149273
Patent
active
048451290
ABSTRACT:
The invention discloses certain diaryl substituted cyclopentane and cyclopentene derivatives useful as PAF inhibitors, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-induced blood platelet aggregation, PAF-mediated broncho-constriction and extravasation, PAF-induced hypotension, PAF-induced ischemic bowel disease and PAF-mediated, endotoxin induced lug injury.
REFERENCES:
patent: 2864868 (1958-12-01), Bader
Allen et al., J. Am. Chem. Soc., vol. 77, No. 8, pp. 2315-2317, (1955).
Doyama et al., Chemical Abstracts, vol. 106, No. 175799b, (1987).
Khand et al., Chemical Abstracts, vol. 90, No. 86801e, (1979).
Anderson Robert C.
Houlihan William J.
Smith Howard C.
Villhauer Edwin B.
Borovian Joseph J.
Gray Bruce
Honor Robert S.
Sandoz Pharm. Corp.
Sharkin Gerald D.
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