Diaryl ethers as opioid receptor antagonist

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S234200, C514S235500, C514S252020, C514S252110, C514S252140, C514S255050, C544S060000, C544S238000, C544S295000, C544S357000, C544S405000

Reexamination Certificate

active

07381719

ABSTRACT:
A compound of the formula (I) wherein the variables X1to X10, R1to R7including R3′, E, v, y, z, A and B are as described, or a pharmaceutically acceptable salt, solvate, enantiomer, racemate, diastereomer or mixtures thereof, useful for the treatment, prevention or amelioration of obesity and Related Diseases is disclosed

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Wentland, et al., “8-Carboxamidocyclazocine Analogues: Redefining the Structure-Activity Relationships of 2,6-Methano-3-Benzazocines,”Bioorganic&Medicinal Chemistry Letters, vol. 11, pp. 623-626 (2001).
Wentland, et al., “3-Carboxamido Analogues of Morphine and Naltrexone: Synthesis and Opioid Receptor Binding Properties,”Bioorganic&Medicinal Chemistry Letters, vol. 11, pp. 1717-1721 (2001).

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