Diaryl antimicrobial agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai

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514480, 514482, 514483, 514487, 514619, 514622, 514634, 514637, 514643, 514647, 514648, 514691, 560 25, 560 27, 560 28, 564237, 564307, 564308, 564309, 564315, 564316, 564317, 564319, 564321, 564322, 564324, 564337, 564341, 564352, 564357, 564353, 564367, 564370, 564374, 564385, 564389, 564390, 564430, 564434, A61K 31135, C07C21702, C07C32128

Patent

active

057734690

ABSTRACT:
The invention relates to diaryl antimicrobial compounds of the general formula: ##STR1## where G, E L, J, q, m, X, Ar, W, p, n and A are as described herein, pharmaceutical compositions containing the compounds, methods for their production and their use in treating bacterial infections.

REFERENCES:
patent: 5145970 (1992-09-01), Pastor
patent: 5643950 (1997-07-01), Demers et al.
Mahan, M. J., J. M. Slauch, and J. J. Mekalanos, Science, 259, 686-688 (1993).
S. Roychoudhury et al., Proc. Nat. Acad. Sci., 90, 965-969 (1993) Inhibitors of Two-Component signal Transduction Systems: Inhibition Of Alginate Gene Activation In Pseudomonas Aeruginosa.

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