Diarrheal antitoxin

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424 85, 514867, A61K 3134, A61K 970, A61K 942

Patent

active

047058048

ABSTRACT:
This disclosure teaches a method of inactivating bacterial toxins, such as produced by Vibrio cholerae and Escherichia coli (hereinafter V. cholerae and E. coli) that are responsible for diarrhea in warm-blooded animals, comprising the placing of an effective dosage of ascorbic acid salts thereof, or derivatives such as the ester ascorbyl palmitate in the intestinal tract.
Definition: Ascorbic acid, salts thereof, and derivatives thereof such as ascorbyl palmetate have been identified as suitable detoxifying material according to this invention. For the sake brevity, the term "ascorbic acid" hereinafter shall include the salts and esters.
Diarrhea as used herein will include other toxins effecting the lower duodenum and intestines.

REFERENCES:
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4377568 (1983-03-01), Chopra
Klenner, "Observations on the Dose and Administration of Ascorbic Acid when Employed Beyond the Range of a Vitamin in Human Pathology" Journal of Applied Nutrition 23, 61-68, 1971.

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