Diaromatic compounds derived from a salicylic unit and their use

Details Diaromatic compounds derived from a salicylic unit and their use Diaromatic compounds derived from a salicylic unit and their use

1993-12-08

1995-12-19

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142375, 514456, 514469, 514510, 514539, 514546, 514562, 514567, 514569, 514618, 514620, 514677, 514681, 514682, 514700, 514717, 514719, 514721, 514732, 544165, 544173, 544174, 546205, 549 23, 549398, 560 10, 560 46, 560 56, 560 66, 560 67, 562427, 562453, 562466, 562475, 564162, 564165, 564171, 564172, 568 44, 568 49, 568326, 568327, 568441, 568632, 568633, 568732, 424401, 424428, A61K 31445, A61K 3119, C07C 6511, C07D21132

Patent

active

054768608

ABSTRACT:
Diaromatic compounds, characterized in that they correspond to the following general formula: ##STR1## in which: R.sub.1 is --CH.sub.3, --CH.sub.2 OH, --COR.sub.8 or --CH.sub.2 OCOR.sub.9, R.sub.8 is H, OH, --OR.sub.10, --N(rr') or alkyl, R.sub.10 is alkyl, alkenyl, aryl or aralkyl, r and r' being H, alkyl, aryl, aralkyl, etc., r and r' together form a heterocycle, R.sub.9 is alkyl, alkenyl or a sugar residue, R.sub.2 and R.sub.3 are --OR.sub.11 or --OCOR.sub.11, R.sub.11 is H, alkyl, fluoroalkyl, aryl or aralkyl, R.sub.3 in addition being H, R.sub.4 is H, OH, alkyl, alkoxy, F, Cl or --CF.sub.3, R.sub.5 and R.sub.7 are H, OH, alkoxy, .alpha.-substituted alkyl or .alpha.,.alpha.'-disubstituted alkyl, etc., R.sub.6 is H, OH, alkyl, alkoxy, cycloalkyl, etc., R.sub.5 and R.sub.7 cannot simultaneously be OH or alkoxy and R.sub.4, R.sub.5, R.sub.6 and R.sub.7 cannot simultaneously be H, R.sub.5 and R.sub.6 or R.sub.6 and R.sub. 7 can form, with the aromatic ring, a ring with 5 or 6 members, X is chosen from amongst:

REFERENCES:
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Carson et al, Chemical Abstracts, vol. 111 (1989) 153363.
CA Previews, 94:553188 (1994).
S. Strickland et al., "Structure-Activity Relationships of a New Series of etinoidal Benzoic Acid Derivatives as Measured by Induction of Differentiation of Murine F9 Teratocarcinoma Cells and Human HL-60 Promyelocytic Leukemia Cells", Cancer Research, 43, pp. 5268-5272, Nov. 1983.
A. K. Verma et al., "Inhibition of 12-O-Tetradecanoylphorbol-13-acetate-induced Ornithine Decarboxylase Activity in Mouse Epidermis by Vitamin A Analogs (Retinoids)", Cancer Research, 38, pp. 793-801, Mar. 1978.
M. M. Goodman et al., "Human Keratinocyte X HeLa Hydrids for Detection of Keratinocyte Differentiation-Specific Antigens", Models Dermatol., 1989, vol. 4, pp. 1-4.
J. M. Geiger et al., "Rat Vaginal Epithelium Assay for Screening Retinoids", Pharmacol Skin., 1989, vol. 3, pp. 141-143.

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