Diaminothiazoles having antiproliferative activity

Details Diaminothiazoles having antiproliferative activity Diaminothiazoles having antiproliferative activity

2006-08-22

2006-08-22

Pryor, Alton (Department: 1616)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C540S484000, C546S001000, C548S100000, C549S001000, C549S200000

Reexamination Certificate

active

07094896

ABSTRACT:
Disclosed are novel diaminothiazoles that are selective inhibitors of Cdk4. These compounds and their pharmaceutically acceptable salts and esters are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds as well as intermediates useful in the preparation of the compounds.

REFERENCES:
patent: WO97/16447 (1997-05-01), None
patent: WO98/33798 (1998-08-01), None
patent: WO99/09030 (1999-02-01), None
patent: WO99/24416 (1999-03-01), None
patent: WO99/21845 (1999-05-01), None
patent: WO99/43675 (1999-09-01), None
patent: WO99/43676 (1999-09-01), None
patent: WO00/12485 (2000-03-01), None
patent: WO 00/26202 (2000-05-01), None
patent: WO00/39101 (2000-07-01), None
patent: WO00/75120 (2000-12-01), None
patent: WO 01/56567 (2001-08-01), None
patent: WO 01/60816 (2001-08-01), None
patent: WO 01/79198 (2001-12-01), None
patent: WO 02/12250 (2002-02-01), None
Senderowicz, A.M., et al. J. Nat'l. Cancer Inst. 2000 vol. 92 pp. 376-387.
Chong, Wesley, K. M., Presentation at Gordon Conference on Medicinal Chemistry, Colby Sawyer College, New London, NH “Novel ATP Site Inhibitors of the Cyclin Dependent Kinases”, Aug. 2, 1999 (Copy of Conference Handout Enclosed).
Fischer et al., Expert Opin. Investig. Drugs 12(6) pp. 955-970 (2003).
Grant et al., Drug Resistance vol. 6, pp. 15-26 (2003).

Affiliated with

Also associated with

Rating

Diaminothiazoles having antiproliferative activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaminothiazoles having antiproliferative activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaminothiazoles having antiproliferative activity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3619144