Diaminopyrimidinecarboxamide derivative

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S227800, C514S235800, C514S252140, C514S275000, C540S575000, C544S060000, C544S122000, C544S295000, C544S323000

Reexamination Certificate

active

07449456

ABSTRACT:
A compound which may be used for the prevention or treatment of respiratory diseases in which STAT 6 is concerned, particularly asthma, chronic obstructive pulmonary disease and the like is provided.A pyrimidine derivative or a salt thereof, which has an arylamino or arylethylamino group which may be substituted with a specified substituent, at the 2-position, amino group substituted with benzyl group or the like, at the 4-position, and carbamoyl group which may be substituted, at the 5-position, is provided.

REFERENCES:
patent: 6200977 (2001-03-01), Cushing et al.
patent: 6432963 (2002-08-01), Hisamichi et al.
patent: 6528513 (2003-03-01), Cushing et al.
patent: 2001/0018436 (2001-08-01), Cushing et al.
patent: 2004/0006068 (2004-01-01), Cushing et al.
patent: WO 99/31073 (1999-06-01), None
patent: WO 99/41253 (1999-08-01), None
patent: WO 00/39101 (2000-07-01), None
Taylor et al., CAPLUS Abstract 55:33107 (1961).
International Search Report dated Jul. 28, 2003.
Supplementary European Search Report dated Feb. 12, 2007.
Hautamaki, et al, “Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice,” Science, 277, pp. 2002-2004 (1997).
Kuperman, et al., “Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma,” Nature Medicine, 8:*, pp. 885-889 (Aug. 2002).
March, et al, “Effects of Concurrent Ozone Exposure On The Pathogenesis of Cigarette Smoke-Induced Emphysema in B6C3F1Mice,” Inhalation Toxicology, 14, pp. 1187-1213 (2002).
Ofulue, A.F., et al., “Time course of neutrophil and macrophage elastinolytic activities in cigarette smoke-induced emphysema,” The American Journal of Physicol. Lung Cell Mol Physiol, 275, pp. L1134-L1144 (1998).
Zheng, et al., “Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase-and-cathepsin-dependent emphysema,” J. of Clinical Investigation, 106, pp. 1081-1093 (Nov. 2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diaminopyrimidinecarboxamide derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaminopyrimidinecarboxamide derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaminopyrimidinecarboxamide derivative will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4035411

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.