Diaminofluorescein derivative

Details Diaminofluorescein derivative Diaminofluorescein derivative

1997-10-17

1999-02-23

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548256, 436172, 25230119, 25230121, C07D31182, C07D48700, G01N 2176

Patent

active

058745904

ABSTRACT:
A compound useful for the measurement of nitrogen monoxide under a substantially neutral condition which is represented by the following formula (I): ##STR1## wherein R.sup.1 and R.sup.2 represent amino groups that substitute at adjacent positions on the phenyl ring; R.sup.3 and R.sup.4 independently represent a hydrogen atom or an acyl group; R.sup.5, R.sup.6, R.sup.7, and R.sup.8 independently represent a hydrogen atom, a C.sub.1-6 alkyl group, allyl group, or a halogen atom.

REFERENCES:
patent: 4321057 (1982-03-01), Buckles
patent: 5686310 (1997-11-01), Haystead et al.
16th Symposium on Medicinal Chemistry 5th Annual Meeting of Division of Medicinal Chemistry-The Pharmaceutical Society of Japan Division of Medicinal Chemstry-Toyama, Nov. 27-29, 1996, entitled: "Development of fluorecent indicators for bioimaging of nitric oxide", at pp. 165-166, published Oct. 23, 1996.
Kojima et al `Development of a fluorescent indicator for nitric oxide based on fluorescein chromophere` CA 128: 254765, 1998.
Maeda et al., Journal of Leukocyte Biology, 56, pp. 588-592, 1994.
Akaike et al., Biochemistry, 32, pp. 827-832, 1993.
Organic Chemicals Catalog, 32, p. 1229, 1994, Tokyo Kasei Co., Ltd.
Hrabie, J. Org. Chem., 58, pp. 1472-1476, 1993.
Kikuchi et al., Biol. Pharm. Bill., 19, pp. 649-651, 1996.
Gendai Kagaku (Chemistry Today), pp. 25-29, Apr. 1994.
Palmer et al., Nature, 327, pp. 524-526, 1987.
Kelm et al., Circulation Research, 66, No. 6, pp. 1561-1575, 1990.
Shibuki, Neroscience Research, 9, pp. 69-76, 1990.
Malinski et al., Nature, 356, pp. 676-678, 1992.
Green et al., Analytical Biochemistry, 126, pp. 131-138, 1982.
"3 Method for the Measurement of NO," by Tetsuo Nagano, pp. 42-52.
"Approach from the Latest Medicine 12, NO," edited by Noboru Toda, published by Medical View Co., Ltd., pp. 42-52.
Archer, FASEB Journal, 7, 349-360, 1993.
Stainton, Analytical Chemistry, 46, No. 11, p. 1616, 1974.
Sawicki et al., Microchemical Journal, 16, pp. 657-672, 1971.
Wiersma, Analytical Letters, 3, No. 3, pp. 123-132, 1970.
Sawicki, Analytical Letters, 4, No. 11, pp. 761-775, 1971.
Damiani et al., Talanta, 33, No. 8, pp. 649-652, 1986.
Misko et al., Analytical Biochemistry, 214, pp. 11-16, 1993.
DOIJN News, No. 74, Information, "A Reagent for the Determination of NO; 2,3-diaminonaphthalene," Dojindo Laboratories Inc., 1995.

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