Diaminocyclobutene-3,4-diones

Details Diaminocyclobutene-3,4-diones Diaminocyclobutene-3,4-diones

1995-05-31

1996-07-16

Davis, Zinna Northington

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514310, 514311, 514313, 514314, 546143, 546146, 546160, 546175, C07D21500, C07D21700, A61K 3147

Patent

active

055367313

ABSTRACT:
The compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are, independent from each other, hydrogen, alkyl, or cyclic or bicyclic alkyl; R.sub.3 is an acyl substituent selected from the group consisting of formyl, alkanoyl, alkenoyl, alkylsulfonyl, aroyl, arylalkenoyl, arylsulfonyl, arylalkanoyl or arylalkylsulfonyl; A is selected from the group consisting of: ##STR2## wherein R.sub.4 is hydrogen, alkyl, perfluoroalkyl, alkoxy, perfluoroalkoxy, amino, alkylamino, dialkylamino, alkylsulfonamido, alkylcarboxamido, nitro, cyano or carboxyl; or a pharmaceutically acceptable salt thereof, are smooth muscle relaxants.

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E. Neuse et al., Liebigs Ann. Chem. 4:619-632 (1973).
Japanese Public Patent Disclosure Bulletin No. 6-92915, Published Apr. 5, 1994.
Ehrhardt et al. Chem. Ber, 10:2506-2523 (1977).

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