Diaminediols for the treatment of Alzheimer's disease

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S423000, C514S448000, C514S471000, C546S304000, C546S314000, C548S190000, C548S200000

Reexamination Certificate

active

07067542

ABSTRACT:
The present invention relates to compounds of formula (I):useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 5145684 (1992-09-01), Liversidge et al.
patent: 5362912 (1994-11-01), Sowin et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5441870 (1995-08-01), Seubert et al.
patent: 5593846 (1997-01-01), Schenk et al.
patent: 5604102 (1997-02-01), McConlogue et al.
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5696270 (1997-12-01), Kempf et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5721130 (1998-02-01), Seubert et al.
patent: 5744346 (1998-04-01), Chrysler et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5892052 (1999-04-01), Kempf et al.
patent: 5912410 (1999-06-01), Cordell
patent: 5942400 (1999-08-01), Anderson et al.
patent: 6045829 (2000-04-01), Liversidge et al.
patent: 6150530 (2000-11-01), Kempf et al.
patent: 6191166 (2001-02-01), Audia et al.
patent: WO 92/00948 (1992-01-01), None
patent: WO 96/19437 (1996-06-01), None
patent: WO 97/19061 (1997-05-01), None
patent: WO 98/22597 (1998-05-01), None
patent: WO 99/64001 (1999-12-01), None
patent: WO 00/03819 (2000-01-01), None
patent: WO 00/17369 (2000-03-01), None
patent: WO 00/47618 (2000-08-01), None
patent: WO 01/10387 (2001-02-01), None
patent: WO 01/23533 (2001-04-01), None
Tossi, Alessandro et al, “Aspartic protease inhibitors,” Eur. J. Biochem. (2000), vol. 257, pp. 1715-1722.
Benedetti, et al., (1997)J. Org. Chem., 62:9348-9353.
Berge, et al., (1977)J. Pharm. Sci. 66(1):1-19.
Chakravarty et al., (1987),Tetrahedron Lett. 28:611-612.
Citron et al., (1992)Nature360:672-674.
Dantzig, et al., (1996)Cancer Research, 56:4171-4179.
Deziel, et al., (1996)J. Org. Chem. 61:2901-2903.
Emilieu, (2000)Arch. Neurol. 57:454-459.
Freudenberger et al., (1989)J. Am. Chem. Soc., 111:8014-8016.
Games et al., (1995)Nature373:523-527.
Gould, (1986)Int. J. Pharm., 33:201-217.
Green & Wuts, (1981) “Protective Groups in Organic Synthesis” John Wiley & Sons, pp. 219-287.
Hardy, (1992)Nature Genet. 1:233-234.
Hussain et al., (1999)Mol. Cell. Neurosci. 14:419-427.
Hyafil, F. (1993)Cancer Research, 53:4595-4602.
Jurczak, et al., (1989)Chem. Rev. 89:149-164.
Kang et al., (1987)Nature325:733-736.
Kang et al., (1996)J. Org. Chem., 61:5528-5531.
Kempf, et al., (1990)J. Med. Chem. 33:2687-2689.
Kempf et al., (1993)J. Med. Chem., 36:320-330.
Kitaguchi et al., (1988)Nature331:530-532.
Konradi et al., (1990)J. Org. Chem. 55:4506-4508.
Konradi et al., (1992)J. Org. Chem. 57:28-32.
Lee et al., (1999)J. Am. Chem. Soc. 121:1145-1155.
Lin et al., (2000),PNAS USA97:1456-1460.
Luo et al., (2001)Nature Neuroscience4:231-232.
Pirttila et al., (1999)Neuro. Lett. 249:21-24.
Randad et al., (1995)Bioorganic&Med. Chem. Ltrs. 5:1707-1712.
Randad et al., (1995)Bioorganic&Med. Chem. Ltrs. 5:2557-2562.
Randad et al., (1996)Bioorganic&Med. Chem. Ltrs. 4:1471-1480.
Randad et al., (1998)Bioorganic&Med. Chem. Ltrs. 8:3537-3542.
Sabbagh, M., et al., (1997)Alz. Dis. Rev. 3:1-19.
Selkoe, (1991)Neuron6:487-498.
Seubert et al., (1992)Nature359:325-327.
Sinha et al., (1999)Nature402:537-540.
Vassar et al., 1999,Science286:735-741.
Witherspoon, et al., (1996)Clin. Cancer Res., 2:7-12.
Yan et al., 1999,Nature402:533-537.
Zuccarello, et al., (1998)J. Org. Chem., 63:4898-4906.
Partial International Search Report for related International Application PCT/US 02/22459.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Diaminediols for the treatment of Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diaminediols for the treatment of Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diaminediols for the treatment of Alzheimer's disease will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3615444

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.