Diamine salts for purification of clavulanic acid

Details Diamine salts for purification of clavulanic acid Diamine salts for purification of clavulanic acid

1993-03-26

1998-04-21

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07B 6302, C07D498047

Patent

active

057419035

ABSTRACT:
A process for the purification of clavulanic acid comprising reacting in an organic solvent impure clavulanic acid with a diamine of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are individually selected from the group consisting of alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms and cycloalkyl alkyl of 3 to 8 cycloalkyl carbon atoms and alkyl of 1 to 8 carbon atoms, all optionally substituted with 1 to 3 members of the group consisting of halogen, --OH, lower alkoxy and carboxy esterified with lower alkyl or R.sub.1 and R.sub.2 or R.sub.3 and R.sub.4 taken with the nitrogen to which they are attached form piperidino and n is an integer from 1 to 10 to form an amine salt selected from the group consisting of ##STR2## recovering the amine salts and acidifying the amine salt to recover purified clavulanic acid.

REFERENCES:
patent: 4454069 (1984-06-01), Cook et al.
patent: 5310898 (1994-05-01), Copar

Affiliated with

Also associated with

Rating

Diamine salts for purification of clavulanic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diamine salts for purification of clavulanic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diamine salts for purification of clavulanic acid will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2058804