Diamine platinum(IV) complexes having mixed carboxylate ligands

Details Diamine platinum(IV) complexes having mixed carboxylate ligands Diamine platinum(IV) complexes having mixed carboxylate ligands

1992-11-19

1994-02-22

Prescott, Arthur C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

540465, C07F 1500, A61K 3128

Patent

active

052888878

ABSTRACT:
Platinum(IV) complexes with mixed carboxylato ligands having the formula: ##STR1## where X.sup.1 and X.sup.2 are carboxylato, or are jointly dicarboxylato, where .sup.1 Y and Y.sup.2 are carboxylato, and where Z is either diaminocyclohexane or ethylenediamine, have been found to have desirable antitumor activity, as well as relatively low levels of toxicity.

REFERENCES:
patent: 3904663 (1975-09-01), Tobe et al.
patent: 4115418 (1978-09-01), Gale et al.
patent: 4137248 (1979-01-01), Gale et al.
patent: 4140707 (1979-02-01), Cleare et al.
patent: 4169846 (1979-10-01), Kidani et al.
patent: 4203912 (1980-05-01), Hydes et al.
patent: 4225529 (1980-09-01), Hydes et al.
patent: 4230631 (1980-10-01), Hydes et al.
patent: 4256652 (1981-03-01), Kidani et al.
patent: 4271085 (1981-06-01), Amundsen et al.
patent: 4431666 (1984-02-01), Bulten et al.
patent: 4466924 (1984-08-01), Verbeek et al.
patent: 4614811 (1986-09-01), Gandolfi
patent: 4657927 (1987-04-01), Cleare et al.
patent: 4661516 (1987-04-01), Brown et al.
patent: 4680308 (1987-07-01), Schwartz et al.
patent: 4716157 (1987-12-01), Bitha et al.
patent: 4760155 (1988-07-01), Heffernan et al.
patent: 4760156 (1988-07-01), Heffernan et al.
patent: 4760157 (1988-07-01), Child et al.
patent: 4845124 (1989-07-01), Kidani et al.
patent: 4861905 (1989-08-01), Nowatari et al.
patent: 5206400 (1993-04-01), Witiak et al.
Perez-Soler et al., "Treatment and Prophylaxis of Experimental Liver Metastases of M5076 Reticulosarcoma with cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum(II) Encapsulated in Multilamellar Vesicles", Cancer Research, 47:6462-6466 (Dec. 1987).
Maeda, et al., "Liposoluble Platinum(II) Complexes with Antitumor Activity", Japan Journal Cancer Research, 77:523-525 (Jun. 1986).
Vollano et al., "Comparative Antitumor Studies on Platinum(II) and Platinum(IV) Complexes Containing 1,2-Diaminocyclohexane", J. Med. Chem., 30:716-719 (1987).
Belg. BE 898,614, "Cis-1,2-Diaminocyclohexane Platinum Complexes", Chem. Abstracts 101:177510w (1984).
Kihari, "Organoplatinum Complexes as Antineoplastics", Chemical Abstracts 105:134160X (1989).
Craciunescu, "On the Preparation, Antitumor and Cyctotoxic Evaluation of Some New Analogues of the Cis-Dichloro (1,2-Diamino-Cyclohexane) Platinum(II) Complex", Eur. J. Med. Chem., 4:353-357 (1984).
Sur, "Effect of Liposomal Encapsulation of Cis-Platinum Diamminodichloride in the Treatment of Ehrlich Ascites Carcinoma", Oncology, 40:372-376 (1983).
Freise, "Pharmacokinetics of Liposome Encapsulated Cisplatin in Rats", Archives etc., 258:180-192 (1982).
Kaledin, "Intralymphatic Administration of Liposome-Encapsulated Drugs to Mice: Possibility for Suppression of the Growth of Tumor Metastases in the Lymph Nodes", JNCL, 66:881-886 (1981).
Deliconstantinos, "Incorporation of Cis-Dichlorobiscyclopentylamineplatinum (II) into Liposomes Enhances its Uptake by ADJ/PC6A Tumors Implanted Subcutaneously into Mice", Biochem. Soc. Trans., 5:1326-1328 (1977).
Yatvin, "Selective Delivery by Hyperthermia of Liposome Encapsulated Cis Dichlorodiamine Platinum(II) and Tumor Growth Delay" (Meeting Abstract) Proc. Am. Assoc. Cancer Res., 21:281 (1980).
Schwartz, "Preparation and Antitumor Evaluation of Water-Soluble Derivatives of Dichloro(1,2-diaminocyclohexane)platinum(II)", Chemical Abstracts, 88:16014K (1978).
Perez-Soler, "Toxicity and Antitumor Activity of cis-Bis-cyclopentenecarboxylato-1,2-diaminocyclohexane Platinum(II) Encapsulated in
The U.S. government owns certain right in this invention.

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