Diamine-platinum (II) complex compounds

Details Diamine-platinum (II) complex compounds Diamine-platinum (II) complex compounds

1989-11-20

1991-02-12

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548402, 546273, A61K 31555, C07D40112, C07D20920, C07D20914

Patent

active

049925539

ABSTRACT:
A compound of the general formula: ##STR1## wherein R.sub.1 is hydrogen, a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.2 is hydrogen or a halogen atom, R.sub.3 is hydrogen or a C.sub.1 -C.sub.6 alkyl group, R.sub.4 is a hydroxy group or a C.sub.2 -C.sub.6 alkanoyloxy group, R.sub.5 is hydrogen or a halogen atom and R.sub.6 is hydrogen or a halogen atom, Alk is a C.sub.2 -C.sub.10 alkylene chain where 4 neighboring CH.sub.2 groups may also be replaced by a 1,4-phenylene ring, A-B is the group HN--CH.sub.2 --CH.sub.2 --NH.sub.2, H.sub.2 N--CH.sub.2 --CH--CH.sub.2 --NH.sub.2 or ##STR2## and R.sub.7 is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group or a phenyl radical and X stands for the equivalent of a physiologically acceptable anion. The compound is useful for the treatment of hormone dependent tumors.

REFERENCES:
patent: 4704464 (1987-11-01), Brunner
Bowler, J. A. C. S. 106, 6102 (1984).
T. A. Connors et al. Platinum Coordination Complexes in Cancer Chemotherapy, Berlin, 1974, pp. 132-136.
Sandra J. Meischen et al., Journ. Nat. Cancer Inst. 57, (1976) pp. 841-845.
Sarma et al., Chem-Biol Interactions, 46 (1983) pp. 219-232.
Lalit Kumar et al., Synthesis and Spectroscopic Studies of Potential Anticancer [Platinum(II)(2,2'-Bipyridine)(Amino acid)].sup.n+ (n=1 or 2) Complexes; Journal of Inorganic Biochemistry, vol. 23 (1985) pp. 1-11.

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