Diamine compound having phosphorylcholine group, polymer...

Organic compounds -- part of the class 532-570 series – Organic compounds – Phosphorus esters

Reexamination Certificate

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C528S072000

Reexamination Certificate

active

08063238

ABSTRACT:
Highly polymerizable diamine compounds having a phosphorylcholine group are disclosed. High-molecular weight polymers are obtained from the highly polymerizable diamine compound having a phosphorylcholine group as a monomer, and the polymers have improved mechanical strength, water resistance and heat resistance while maintaining excellent biocompatibility and processability of MPC polymers. Processes for producing the polymers are disclosed. The diamine compounds having a phosphorylcholine group are represented by Formula (I). The polymers contain at least 1 mol % of a specific structural unit with a phosphorylcholine group represented by Formula (II) and have a number average molecular weight of not less than 5,000. In the processes, the diamine compound is used as a monomer.

REFERENCES:
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Kazuhiko Ishihara et al., “Preparation of Phospholipid Polymers and Their Properties as Polymer Hydrogel Membranes”, Polymer Journal, 1990, pp. 355-360, vol. 22, No. 5.
Kazuhiko Ishihara et al., “New development of antithrombogenic materials”, Geka (Surgery), 1999, pp. 132-135 vol. 61, No. 2, plus English-language translation (3 pp.).

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