Dialysis on microchips using thin porous polymer membranes

Details Dialysis on microchips using thin porous polymer membranes Dialysis on microchips using thin porous polymer membranes

2007-09-04

2007-09-04

Cecil, Terry K. (Department: 1723)

Liquid purification or separation

Casing divided by membrane into sections having inlet

C436S178000, C436S053000, C422S068100, C422S105000

Reexamination Certificate

active

10443491

ABSTRACT:
Laser-induced phase-separation polymerization of a porous acrylate polymer is used for in-situ fabrication of dialysis membranes inside glass microchannels. A shaped 355 nm laser beam is used to produce a porous polymer membrane with a thickness of about 15 μm, which bonds to the glass microchannel and form a semi-permeable membrane. Differential permeation through a membrane formed with pentaerythritol triacrylate was observed and quantified by comparing the response of the membrane to fluorescein and fluorescently tagging 200 nm latex microspheres. Differential permeation was observed and quantified by comparing the response to rhodamine 560 and lactalbumin protein in a membrane formed with SPE-methylene bisacrylamide. The porous membranes illustrate the capability for the present technique to integrate sample cleanup into chip-based analysis systems.

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