Dialkenyl derivatives of xanthine, pharmaceutical compositions a

Details Dialkenyl derivatives of xanthine, pharmaceutical compositions a Dialkenyl derivatives of xanthine, pharmaceutical compositions a

1986-07-14

1988-09-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544267, 544273, C07D23936, A61K 3152

Patent

active

047726075

ABSTRACT:
The present invention is various novel diallyl analogs of xanthine. Additionally, the invention is pharmaceutical compositions having as the active compound diallyl analogs of xanthines and methods of use therefor. Processes of preparation of diallyl analogs of xanthine are also the invention. The use of the analogs relates particularly to a desirable affinity at adenosine receptors, particularly the A.sub.1 receptor. The analogs are adenosine receptor antagonists. The analogs, thus, for example provide activity for use as a CNS stimultant cognition activator, antifibrillatory agent, and bronchodilator.

REFERENCES:
patent: 3624215 (1971-11-01), Skokie
patent: 3624216 (1971-11-01), Skokie
patent: 4089959 (1978-05-01), Diamond
patent: 4364922 (1981-12-01), Berne et al.
patent: 4452788 (1984-06-01), Bristol et al.
patent: 4469698 (1984-09-01), Ohilippossian
patent: 4593095 (1986-06-01), Snyder et al.
Schwabe, Pharmacol., vol. 330, pp. 212-221 (1985).
Jacobsen, J. Med. Chem., vol. 28, pp. 1334-1340 (1985).
Hamilton et al., J. Med. Chem., vol. 28, pp. 1071-1079, (1985).
Daly et al., J. Med. Chem., vol. 28, pp. 487-492 (1985).

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