Diagnostics method

Details Diagnostics method Diagnostics method

2003-07-07

2009-08-11

Graser, Jennifer E (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S004000, C435S007100, C435S007920, C530S300000, C530S350000, C424S248100

Reexamination Certificate

active

07572597

ABSTRACT:
Method of diagnosing in an individual recent exposure to an agent which is a pathogen, vaccine or any other moiety which induces a cellular response, said method comprising determining in vitro whether the T cells of the individual recognise a protein from said agent having a length of at least 30 amino acids, to a greater extent than one or more peptide epitopes from the agent, a greater extent of recognition of the protein indicating that the individual has recently been exposed to the agent.

REFERENCES:
patent: WO 00/26248 (2000-05-01), None
patent: WO 01/04151 (2001-01-01), None
patent: WO 02/054072 (2002-07-01), None
Mikayama et al. (Nov. 1993. Proc.Natl.Acad.Sci. USA, vol. 90 : 10056-10060).
Lalvani et al. “Enhanced contact tracing and spatial tracking of mycobacterium tuberculosis infection by enumeration of antigen-specific T cells” The Lancet 357:2017-2021 (2001).
Pathan et al. “Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in mycobacterium tuberculosis-infected individuals: Associations with clinical disease state and effect of treatment” J. Immunol. 167:5217-5225 (2001).

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