Diagnostics for mycobacteria in public health, medical, and vete

Details Diagnostics for mycobacteria in public health, medical, and vete Diagnostics for mycobacteria in public health, medical, and vete

1992-04-14

1993-07-06

Moskowitz, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 29, 435 34, 435 91, 436501, 436 94, 935 77, 935 78, 536 231, 536 237, C12Q 168, C12Q 102, G01N 33566, C07H 1512

Patent

active

052253244

ABSTRACT:
The invention relates to a family of DNA insertion sequences (ISMY) of mycobacterial origin and other DNA probes which may be used a probes in assay methods for the identification of mycobacteria and the differentiation between closely related mycobacterial strains and species. In one method the probes are used to distinguish pathogenic M. paratuberculosis from M. avium, which finds an application in the diagnosis of Crohn's disease in humans and Johne's disease in animals. The use of ISMY, and of proteins and peptides encoded by ISMY, in vaccines, pharmaceutical preparations and diagnostic test kits is also disclosed.

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