Diagnostics based on tetrazolium compounds

Details Diagnostics based on tetrazolium compounds Diagnostics based on tetrazolium compounds

2006-12-05

2006-12-05

Le, Long V. (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S014000, C435S025000, C435S287700, C435S287800, C435S096000, C435S970000, C436S110000, C436S537000, C422S051000, C422S051000

Reexamination Certificate

active

07144709

ABSTRACT:
A reagent is suitable for measuring the concentration of an analyte in a hemoglobin-containing biological fluid, such as whole blood. The reagent comprises a flavin-dependent enzyme that has specificity for the analyte, a flavin cofactor if, and only if, a flavin is not bound to the enzyme, a tetrazolium dye precursor, an electron transfer agent, and a nitrite salt. The reagent causes dye formation that is a measure of the analyte concentration. The nitrite salt suppresses interfering dye formation caused non-enzymatically by the hemoglobin. Preferably, the reagent is used in a dry strip for measuring glucose in whole blood.

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