Diagnostic uses of IGFBP-2

Details Diagnostic uses of IGFBP-2 Diagnostic uses of IGFBP-2

1996-08-22

2000-10-03

Nelson, Peter A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 530399, A01N 3718

Patent

active

H00018996

ABSTRACT:
A method for determining a concentration of IGF-I that defines a therapeutically effective dose of IGF-I, i.e., a dose that will provide a therapeutic response in the treatment of neurological disorders for which IGF-I is utilized (including peripheral neuropathy, diabetic neuropathy, post-polio syndrome, small fiber neuropathy, ALS, and MS) is described. The method comprises determining whether a particular dose of IGF-I causes a 1.5 fold or greater increase in the homeostatic concentration of plasma IGFBP-2 in a mammal that has previously received a defined dose of IGF-I. The method of the invention can also be used to determine whether or not biological tolerance has developed to a particular dose of IGF-I.

REFERENCES:
patent: 5128320 (1992-07-01), Hahn et al.
patent: 5565428 (1996-10-01), Clark et al.

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