Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1993-05-03
1996-12-03
Gitomer, Ralph J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
435 4, 436811, C12Q 102, C12Q 100
Patent
active
055807488
ABSTRACT:
The present invention is a method for the diagnosis of Alzheimer's disease using human cells. Specifically, the method detects differences between potassium channels in cells from Alzheimer's patient and normal donors, and differences in intracellular calcium concentrations between Alzheimer's and normal cells in response to chemicals known to increase intracellular calcium levels.
REFERENCES:
patent: 4925664 (1990-05-01), Jackson
Etcheberrigaray R., Potassium Channel Dysfunction . . . Proc Natl Acad Sci, vol. 90 pp. 8209-8213 1993.
Adunsky A., Increased Cytosolic Free Calcium In Lymphocstes . . . J Of Nguroimm 33 (1991) 167-172.
Ikeda, M., Selective Reduction of .sup.125 I Apamin Binding . . . Brain Research 567 (1991) 51-56.
Crespo D., The Influence Of Age On Supraoptic . . . Mech Of Ageing & Development 62 (1992) 223-228.
Etcheberrigaray R., Potassium Channel Dysfunction . . . Proc Natl Acad Sci USA 90 (1993) 8209-8213.
E. Ito et al., (1993) Neuroscience Research, vol. 18: Abstract 615 "A laboratory diagnosis of Alzheimer's Disease with Patch-Clamp and Ca2.sup.+ -imaging techniques".
R. Etcheberrigaray et al. (1993) Proceedings Of The National Academy Of Sciences (USA) vol. 90, No. 17. 8209-8213 "Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer disease."
E. Ito et al. (1994) Proceedings Of The National Academy Of Sciences (USA) vol. 91, No. 2, pp. 534-538 "Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease".
H-M. Huang et al. (1994) Neurobiology Of Aging, vol. 12: pp. 469-473 "Inositol Phosphates and Intracellular Calcium After Bradykinin Stimulation in Fibroblasts From Young, Normal Aged and Alzheimer Donors".
A. Grossmann et al., (1993) Neurobiology Of Aging, vol. 14, No. 2: 177-185 "Intracellular Calcium Response Is Reduced in CD4+ Lymphocytes in Alzheimer's Disease and in Older Persons with Down's Syndrome".
B. Sakmann et al. (1984) Ann. Rev. Physiol., vol. 46: 455-472 "Patch Clamp Techiques for Studying Ionic Channels in Excitable Membranes".
C. Peterson et al. (1988) Neurobiology Of Aging, vol. 9, No. 3: 261-266 "Altered response of Fibroblasts From Aged and Alzheimer Donors to Drugs That Elevate Cytosolic Free Calcium".
A. F. Ghuysen-Itard et al. (1993) Gerontology, vol. 39: 163-169 "Loss of Calcium-Homeostatic Mechanisms in Polymorphouclear Leukocytes of Demented and Nondemented Elderly Subjects".
Etcheberrigaray, R. et al., Soc. Neurosci Abstract, vol. 18, Oct. 25-30, 1992 "Distinguishing Features of Potassium Channels in Fibroblasts From Alzheimer Aged and Young Donors".
Dewar, D. et al., Neurobiol. Aging. vol. 13 (Suppl. 1), Jul. 12-17, 1992 "Multiple Ion Channel Binding Sites are Differentilly Altered in Alzheimer's Disease Cortex".
Ikeda, M. et al. Brain Res. vol. 567, pp. 51-56 (1991) "Selective Reduction of Iodine-125 Apamin Binding Sites in Alzheimer's Hippocampus: A Quantitative Autoradiographic Study".
Etcheberrigaray, R. et al. Proc. Nat'l Ac. Sciences, vol. 89, pp. 7184-7188 (1992) "Classical Conditioning and Protein Kinase C Activation Regulate the Same Single Potassium Channel in Hermissenda Crassicornis Photoreceptors".
Sakmann, B. and Neker, E., Ann. Rev. Physiol. vol. 46, pp. 455-472 (1984) "Patch Clamp Techniques For Studying Ionic Channels in Excitable Membranes".
Alkon Daniel L.
Etcheberrigaray Rene
Gibson Gary E.
Ito Etsuro
Gitomer Ralph J.
The United States of America as represented by the Department of
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