Diagnostic testing process

Details Diagnostic testing process Diagnostic testing process

2010-09-02

2011-11-29

Chin, Chris L (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

C422S401000, C422S402000, C422S408000, C422S420000, C422S425000, C422S430000, C435S287200, C435S287700, C435S287900, C435S288500, C435S810000, C435S973000, C436S514000, C436S810000

Reexamination Certificate

active

08067246

ABSTRACT:
A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analyzed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus o permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.

REFERENCES:
patent: 4233402 (1980-11-01), Maggio et al.
patent: 4246339 (1981-01-01), Cole et al.
patent: 4299916 (1981-11-01), Litman et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4391904 (1983-07-01), Litman et al.
patent: 4435504 (1984-03-01), Zuk et al.
patent: 4623461 (1986-11-01), Hossom et al.
patent: 4632901 (1986-12-01), Valkirs et al.
patent: 4693834 (1987-09-01), Hossom
patent: 4877586 (1989-10-01), Davaney et al.
patent: 4912034 (1990-03-01), Kalra et al.
patent: 4916056 (1990-04-01), Brown, III et al.
patent: 4956302 (1990-09-01), Gordon et al.
patent: 5008080 (1991-04-01), Brown et al.
patent: 5137691 (1992-08-01), Parker
patent: 5149622 (1992-09-01), Brown et al.
patent: 5167924 (1992-12-01), Clark
patent: 5185127 (1993-02-01), Vonk
patent: 5366867 (1994-11-01), Kawakami et al.
patent: 5391478 (1995-02-01), Greene et al.
patent: 5514602 (1996-05-01), Brooks et al.
patent: 5571667 (1996-11-01), Chu et al.
patent: 5658801 (1997-08-01), Poissant et al.
patent: 5710049 (1998-01-01), Noppe et al.
patent: 5763262 (1998-06-01), Wong et al.
patent: 5885526 (1999-03-01), Chu
patent: 6057165 (2000-05-01), Mansour
patent: 6312888 (2001-11-01), Wong et al.
patent: 6565808 (2003-05-01), Hudak et al.
patent: 7205159 (2007-04-01), Cole et al.
patent: 7875435 (2011-01-01), Marlborough et al.
patent: 2002/0064888 (2002-05-01), Maynard et al.
patent: 2003/0049857 (2003-03-01), Chan
patent: 2003/0207442 (2003-11-01), Markovsky et al.
patent: 2005/0164404 (2005-07-01), Marlborough
patent: 0 447 154 (1991-09-01), None
patent: 0 319 294 (1994-10-01), None
patent: 0 651 249 (1995-05-01), None
patent: WO 96/07099 (1996-03-01), None
patent: WO 96/35123 (1996-11-01), None
patent: WO 97/06437 (1997-02-01), None
patent: WO 98/13519 (1998-04-01), None
patent: WO 98/32018 (1998-07-01), None
patent: WO 99/36773 (1999-07-01), None
patent: WO 99/64863 (1999-12-01), None
patent: WO 00/55626 (2000-09-01), None
patent: WO 01/84153 (2001-11-01), None
patent: WO 02/31465 (2002-04-01), None
patent: WO 03/016902 (2003-02-01), None
Verheijen, R., “Development of a One Step Strip Test for the Detection of (Dihydro)streptomycin Residues in Raw Milk,”Food and Agricultural Immunology 12:31-40 (2000).
International Search Report for PCT/AU2002/001684, date of mailing Mar. 11, 2003.
International Preliminary Examination Report for PCT/AU2002/001684, completion date of report Feb. 6, 2004.
International Search Report for PCT/AU2002/01119 date of mailing Nov. 25, 2002.
Abdel-Hamid, I., et al., “Flow-through immunofiltration assay system for rapid detection ofE. coliO157:H7,”Biosensors Bioelectornics, 14 3(L 309-316 (1999).
Gennaro, M.L., “Immunologic Diagnosis of Tuberculois,”Clinical Infectious Diseases, 30 (Suppl. 3): S243-S246 (2000).

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