Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-01-25
2011-01-25
Chin, Christopher L (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C422S051000, C435S288500, C436S524000, C436S525000, C436S538000, C436S807000
Reexamination Certificate
active
07875435
ABSTRACT:
A method and apparatus for use in a flow through assay process is disclosed. The method is characterized by a “pre-incubation step” in which the sample which is to be analysed (typically for the presence of a particular protein), and a detection analyte (typically one or more antibodies bound to colloidal gold or a fluorescent tag) which is known to bind to the particular protein may bind together for a desired period of time. This pre-incubation step occurs before the mixture of sample and detection analyte come into contact with a capture analyte bound to a membrane. The provision of the pre-incubation step has the effect of both improving the sensitivity of the assay and reducing the volume of sample required for an assay. An apparatus for carrying out the method is disclosed defining a pre-incubation chamber for receiving the sample and detection analyte having a base defined by a membrane and a second membrane to which a capture analyte is bound. In one version the pre-incubation chamber is supported above the second membrane in one position but can be pushed into contact with the membrane carrying the capture analyte thus permitting fluid transfer from the incubation chamber through the capture membrane. In another version the membrane at the base of the incubation chamber is hydrophobic and its underside contacts the capture membrane and when a wetting agent is applied to the contents of the pre-incubation chamber fluid transfer occurs.
REFERENCES:
patent: 4246339 (1981-01-01), Cole et al.
patent: 4877586 (1989-10-01), Devaney, Jr. et al.
patent: 4912034 (1990-03-01), Kalra et al.
patent: 5008080 (1991-04-01), Brown, III et al.
patent: 5137691 (1992-08-01), Parker
patent: 5149622 (1992-09-01), Brown et al.
patent: 5185127 (1993-02-01), Vonk
patent: 5366867 (1994-11-01), Kawakami et al.
patent: 5391478 (1995-02-01), Greene et al.
patent: 5514602 (1996-05-01), Brooks et al.
patent: 5658801 (1997-08-01), Poissant et al.
patent: 5710049 (1998-01-01), Noppe et al.
patent: 5763262 (1998-06-01), Wong et al.
patent: 5885526 (1999-03-01), Chu
patent: 6057165 (2000-05-01), Mansour
patent: 6312888 (2001-11-01), Wong et al.
patent: 6565808 (2003-05-01), Hudak et al.
patent: 2002/0064888 (2002-05-01), Maynard et al.
patent: 2003/0049857 (2003-03-01), Chan
patent: 2003/0207442 (2003-11-01), Markovsky et al.
patent: 2005/0124077 (2005-06-01), Cole et al.
patent: 0 447 154 (1991-09-01), None
patent: 0 651 249 (1995-05-01), None
patent: WO 96/07099 (1996-03-01), None
patent: WO 96/35123 (1996-11-01), None
patent: WO 98/13519 (1998-04-01), None
patent: WO 98/32018 (1998-07-01), None
patent: WO 99/36773 (1999-07-01), None
patent: WO 99/64863 (1999-12-01), None
patent: WO 00/55626 (2000-09-01), None
patent: WO 01/84153 (2001-11-01), None
patent: WO 02/31465 (2002-04-01), None
patent: WO 03/016902 (2003-02-01), None
Verheijen, R., “Development of a One Step Strip Test for the Detection of (Dihydro)streptomycin Residues in Raw Milk,”Food and Agricultural Immunology 12:31-40 (2000).
Cole Robert Alan
Hunter William Samuel
Marlborough David Ian
Sloane Andrew John
Chin Christopher L
Hamilton Brook Smith & Reynolds P.C.
Proteome Systems Ltd
LandOfFree
Diagnostic testing process does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic testing process, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic testing process will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2704926