Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-05-30
1998-02-10
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435961, 435962, 435975, 436172, 436175, 436825, 5303884, 5303911, 5303993, G01N 33569
Patent
active
057168296
ABSTRACT:
Methods and reagents are provided for a novel immunodiagnostic test for the presence of P. aeruginosa in a biological sample. Monoclonal antibodies are employed which bind to an outer membrane protein antigen, which may be exposed by a solubilizing reagent. The antibody binds substantially all strains of P. aeruginosa. No cross-reactivity with other species of Pseudomonas or with other clinically significant gram-negative or gram-positive species is observed. Conjugating the monoclonal antibody of the invention with a fluorescent label provides for a rapid and sensitive direct immunofluorescent test for P. aeruginosa.
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Darveau Richard P.
Lostrom Mark E.
Rosok Mae Joanne
Genetic Systems Corporation
Stucker Jeffrey
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