Diagnostic test for malabsorption

Details Diagnostic test for malabsorption Diagnostic test for malabsorption

1977-12-02

1980-05-20

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

A61K 2900

Patent

active

042039673

ABSTRACT:
An improved diagnostic method for detecting malabsorption comprising the oral ingestion by the patient of an effective amount of N-(2-aminoethyl)-glycine (Aeg), collecting the urine for eight hours post ingestion, then detecting the amount of N-(2-aminoethyl)-glycine in the urine by contacting the urine with an indicator substance which indicates the presence of N-(2-aminoethyl)-glycine. Suitable reagents include nihydrin, 2-methoxy-2,4-diphenyl-3-(2H)-furanone, o-phthalaldehyde and fluorescamine, with fluorescamine being preferred. The determination can be made quantitative by treating the urine with a source of active chlorine or bromine prior to contact with the indicator.

REFERENCES:
J. Chem. Soc. (C), 3393 (1971).

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