Diagnostic test for interstitial cystitis

Details Diagnostic test for interstitial cystitis Diagnostic test for interstitial cystitis

1996-02-23

1998-10-20

Leary, Louise

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

435 72, 435 721, 435 71, 435 34, 435378, 435377, 435374, 435383, 435404, 435391, 435 29, 435 30, 424558, 436 74, 436 63, C12Q 102, C12Q 104, G01N 3353, G01N 3320

Patent

active

058244930

ABSTRACT:
A method of diagnosing interstitial cystitits in an individual and a kit for the method, comprising the steps of: obtaining primary cultures of urothelial cells; selecting urothelial cells of basal type and producing secondary cultures; measuring in secondary cultures (1) percentage of single cells and percentage of large colonies; (2) determining proliferative ability; (3) determining differentiation ability; (4) determining the percentage of large colonies that express phosphotyrosine and/or nitrotyrosine; (5) measuring the percentage of apoptotic cells; (6) measuring the percentage of large colonies; and (7) comparing the percentage of the colonies to baseline values of the same parameters determined in samples of similarly cultured urothelial cells taken from individuals not suspected of having interstitial cystitis.

REFERENCES:
patent: 4643971 (1987-02-01), Fradet et al.
patent: 5039611 (1991-08-01), Fradet
patent: 5234698 (1993-08-01), Fahim
patent: 5318891 (1994-06-01), Elgebaly

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