Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2005-10-20
2008-12-09
Myers, Carla (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S091200, C536S023500, C536S024310, C536S024330
Reexamination Certificate
active
07462455
ABSTRACT:
The invention relates to a method for identifying dogs which are genetically normal, heterozygous for, or homozygous for the mutation primarily responsible for Collie eye anomaly (CEA). The method comprises the steps of obtaining a biological sample from a dog and testing DNA in the biological sample for the presence or absence of a 7.8 kilobase deletion within chromosome37in which the CEA mutation is located. No deletion is indicative of a normal dog. A deletion on one allele of chromosome37is indicative of a dog that is heterozygous for the CEA mutation. A deletion in both alleles of chromosome37are indicative of a dog that is homozygous for the CEA mutation. Also provided is a kit for identifying a dog as normal, heterozygous for, or homozygous for the CEA mutation.
REFERENCES:
Lowe et al., Linkage Mapping of the Primary Disease Locus for Collie Eye Anomaly, Genomics 82 (2003) 86-95.
Acland Gregory M.
Aguirre Gustavo D.
Akey Dayna
Goldstein Orly
Kukekova Anna V.
Cornell Research Foundation Inc.
Hodgson & Russ LLP
Myers Carla
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