Diagnostic test and reagent therefor

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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23230B, 424 8, 424 11, 424 13, 424 78, 424 85, 424 86, 424 87, 424 88, 424 89, 424 92, G01N 128, G01N 3348, G01N 3354

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043105084

ABSTRACT:
A highly sensitive direct particle agglutination test capable of routinely detecting as little as 0.2 nanograms of antigen per milliliter of clinical fluid and characterized by uniform sensitivity as well as stability is disclosed as well as coated particles having a sensitivity of 0.2 nanograms antigen per milliliter and methods for preparing such coated particles. In addition, a method to reduce the frequency of non-specific agglutination with human sera to 2% or less is described.

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Kabat, Structural Concepts in Immuno. & Immunochem. Holt, Rinehart & Winston, N.Y. 2nd Ed. 1976, pp. 238-258, 267-269.
Fritz, The J. of Immunol., vol. 108, 1972, pp. 108-111.

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