Diagnostic system employing a unitary substrate to immobilize mi

Details Diagnostic system employing a unitary substrate to immobilize mi Diagnostic system employing a unitary substrate to immobilize mi

1991-12-13

1995-07-11

Saunders, David

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

435 792, 435 794, 436518, 436531, 436534, 436805, 436807, 436810, G01N 33543, G01N 33545, G01N 33546

Patent

active

054321000

ABSTRACT:
In a diagnostic apparatus system, a one piece porous substrate is provided in a container. The substrate serves both to extract an antigen in or on a top layer thereof with the remainder of the substrate serving as a reservoir. The pores in the top surface of the substrate are microscopic for entrapment of microspheres carrying antibodies. A target antigen in a test sample attaches to the antibodies when the test sample is poured through the top layer. The pores in all but the top layer of the substrate have a much greater pore size to comprise tile reservoir portion of the substrate.

REFERENCES:
patent: 4059685 (1977-11-01), Johnson
patent: 4340564 (1982-07-01), Harte et al.
patent: 4632901 (1986-12-01), Valkirs et al.
patent: 4774192 (1988-09-01), Terminiello et al.
patent: 4833087 (1989-05-01), Hinckley
Petrucci, General Chemistry, (Macmillan Publishing Company, New York), 4th Ed., 1985, p. 287.

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