Image analysis – Applications – Biomedical applications
Reexamination Certificate
2008-03-11
2008-03-11
Ahmed, Samir (Department: 2624)
Image analysis
Applications
Biomedical applications
C436S063000
Reexamination Certificate
active
10602756
ABSTRACT:
A biological tissue sample is scanned in a single pass to produce an image and corresponding optical-density data. A conventional computerized algorithm is used to identify, isolate and produce segmented images of nuclei contained in the image. The OD values corresponding to nuclear chromatin are used to identify numerical patterns known to have statistical significance in relation to the health condition of the biological tissue. These patterns are analyzed to detect pre-neoplastic changes in histologically normal-appearing tissue that suggest a risk for the development of a pre-malignant and a potentially malignant lesion. This information is then converted to a visually perceptible form incorporated into the image of the tissue sample and is displayed for qualitative analysis by a pathologist.
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patent: 6204064 (2001-03-01), Alberts et al.
patent: 2003/0032017 (2003-02-01), Anderson et al.
E. Bengtsson et al., “Densitometry, Morphometry and Texture Analysis as Tools in Quantitative Cytometry and Automated Cancer Screening,” Grohs and Husain OAN, editors, 1994. p. 21-43.
Ahmed Samir
Dmetrix, Inc.
Durando Antonio R.
Tabatabai Abolfazl
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