Diagnostic procedures using 129 Xe spectroscopy...

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

Reexamination Certificate

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C436S173000, C600S410000, C600S420000

Reexamination Certificate

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07357917

ABSTRACT:
An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized129Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chemical shifts and comparing the observed magnitudes to those of healthy individuals. Preferably, the method includes subtracting substantial backgrounds and accounting for secondary conditions such as the polarization of hyperpolarized gas administered. Additionally, a quantitative analysis of hyperpolarized129Xe spectra advantageously allows, a physician to establish the extent of disease progression. Advantageously, this method can be used regardless of the method of hyperpolarized129Xe administration.

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