Diagnostic probe for diabetes type I predisposition

Details Diagnostic probe for diabetes type I predisposition Diagnostic probe for diabetes type I predisposition

1987-10-29

1991-08-13

Wax, Robert A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 27, C12Q 168, C07H 1512

Patent

active

050396064

ABSTRACT:
An oligonucleotide probe for diagnosing predeposition or susceptibility to type I diabetes, capable of specifically hybridizing with the gene sequence

REFERENCES:
Kim, S. J., et al., "Identification of a Polymorphic Variant Associated with HLA-DQw3 . . . ", Proc. Natl. Acad. Sci., vol. 82, pp. 8139-8143, 12/85.
Gregersen et al., "Molecular Diversity of HLA-DR4 Haplotypes", Proc. Natl. Acad. Sci., vol. 83, pp. 2642-2646, 4/86.
Nepom, B. S., et al., Specific HLA-DR4-Associated Histocompatibility Molecules Characterize Patients with Seropositive Juvenile Rheumatoid Arthritis, J. Clin. Invest., 74:287-291, 1984.
Holbeck, S. L., and G. T. Nepom, Exon-Specific Oligonucleotide Probes Localize HLA-DQ.sub..beta. Allelic Polymorphisms, Immunogenetics, 24:251-258, 1986.
Nepom, G. T., et al., Specific HLA Class II Variants Associated with IDDM, in The Immunology of Diabetes Mellitus, M. Jaworski et al., eds., Elsevier Science Publishers, pp. 9-20, 1986.
Nepom, G. T., et al., Identification of HLA-Dw14 Genes in DR4.sup.+ Rheumatoid Arthritis, The Lancet, ii:1002-1005, Nov. 1986.
Nepom, G. T., et al., The Molecular Basis for HLA Class II Associations with Rheumatoid Arthritis, J. Chin. Immunol., 7(1):1-7, 1987.
Schreuder, G. M., Th., et al., HLA-DQ Polymorphism Associated with Resistance to Type 1 Diabetes Detected with Monoclonal Antibodies, Isoelectric Point Differences, and Restriction Fragment Length Polymorphism, J. Exp. Med., 164:938-943, Sep. 1986.
Todd, J. A., et al., HLA-DQ2.beta. Gene Contributes to Susceptibility and Resistance to Insulin-Dependent Diabetes Mellitus, Nature, 329:599-604, Oct. 15, 1987.
Michelsen, B., and A. Lernmark, Molecular Cloning of Polymorphic DNA Endonuclease Fragment Associates Insulin-Dependent Diabetes Mellitus with HLA-DQ, J. Clin. Invest., 79:1144-1152, Apr. 1987.
Nepom, B. S., et al., Specific Genomic Markers for the HLA-DQ Subregion Discriminate between DR4.sup.+ Insulin-Dependent Diabetes Mellitus and DR4.sup.+ Seropositive Juvenile Rheumatoid Arthritis, J. Exp. Med., 164:345-350, Jul. 1986.
Radka, S. F., et al., Molecular Complexity of HLA-DQw3: the TA10 Determinant is Located on a Subset of DQw3.beta. chains, Human Immunology, 18:287-300, 1987.
Kwok, W. W., et al., Mutational analysis of the HELA-DQ3.2 Insulin-Dependent Diabetes Mellitus Susceptibility Gene, Proc. Natl. Acad. Sci. USA, 86:1027-1030, Feb. 1989.

Affiliated with

Also associated with

Rating

Diagnostic probe for diabetes type I predisposition does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnostic probe for diabetes type I predisposition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic probe for diabetes type I predisposition will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1526957