Chemistry: analytical and immunological testing – Peptide – protein or amino acid – Amino acid or sequencing procedure
Reexamination Certificate
2006-12-26
2006-12-26
Wallenhorst, Maureen M. (Department: 1743)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
Amino acid or sequencing procedure
C436S063000, C436S086000, C436S089000, C436S161000, C073S061520, C073S061550, C210S656000
Reexamination Certificate
active
07153692
ABSTRACT:
The present invention exploits the discovery that amounts of uracil and thymine metabolites, especially β-aminoisobutyric acid, in various bodily fluids, especially urine, are correlated with the occurrence of epilepsy when compared to matched control subjects. Analytical and diagnostic protocols, including a novel high performance liquid chromatography system, for use in the invention are disclosed.
REFERENCES:
patent: 4474888 (1984-10-01), Gindler et al.
patent: 5995868 (1999-11-01), Dorfmeister et al.
patent: 6451761 (2002-09-01), van Gelder et al.
patent: 2003/0114441 (2003-06-01), Weaver et al.
van Gennip et al. Clinical Chemistry, vol. 39, No. 3, 1993, pp. 380-385.
De Guevara et al. Journal of Chromatography, vol. 528, 1990, pp. 35-41.
Abe T, et al. High-performance liquid chromatographic determination of beta-alanine, beta-aminoisobutyric acid and gamma-aminobutyric acid in tissue extracts and urine of normal and (aminooxy)acetate-treated rats. J Chromatogr B Biomed Sci Appl. Aug. 7, 1998;712(1-2):43-9.
Araki K, et al. Alteration of amino acid content of cerebrospinal fluid from patients with epilepsy. Acta Neurol Scand. Dec. 1988;78(6):473-9.
Bakkeren JAJM, et al. Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency. Clin Chim Acta. Jul. 31, 1984;140(3):247-56.
Beyer C, et al. Prevention of the convulsant and hyperalgesic action of strychnine by intrathecal glycine and related amino acids. Pharmacol Biochem Behav. Jan. 1988;29(1):73-8.
Braakhekke JP, et al. Dihydropyrimidine dehydrogenase deficiency. Neurological aspects. J Neurol Sci. Mar. 1987;78(1):71-7.
Carducci C, et al. Automated method for the measurement of amino acids in urine by high-performance liquid chromatography. J Chromatogr A. Apr. 5, 1996;729(1-2):173-80.
Choquet D, et al. Does beta-alanine activate more than one chloride channel associated receptor? Neurosci Lett. Feb. 3, 1988;84(3):329-34.
Crawford PM, et al. GABA and amino acid concentrations in lumbar CSF in patients with treated and untreated epilepsy.Epilepsy Res. Nov.-Dec. 1987;1(6):328-38.
Curtis DR, et al. A pharmacological study of the depression of a spinal neurones by glycine and related amino acids. Exp Brain Res. 1968;6(1):1-18.
Curtis DR, et al. Antagonism between bicuculline and GABA in the cat brain. Brain Res. Oct. 8, 1971;33(1):57-73.
Curtis DR, et al. Bicuculline, an antagonist of GABA and synaptic inhibition in the spinal cord of the cat. Brain Res. Sep. 10, 1971;32(1):69-96.
Davidson DLW, et al. Ouabain induced seizures: site of production and response to anticonvulsants. Can J Neurol Sci. Nov. 1978;5(4):405-11.
De Abreu RA, et al. High-performance liquid chromatographic determination of purine and pyrimidine bases, ribonucleosides, deoxyribonucleosides and cyclic ribonucleotides in biological fluids. J Chromatogr. Apr. 16, 1982;229(1):67-75.
DeFeudis FV, et al. Is Beta-alanine an inhibitory neurotransmitter? Gen Pharmacol. 1977;8(3):177-80.
del Rio RM, et al. Contents of beta-alanine and gamma-aminobutyric acid in regions of rat CNS.Exp Brain Res. Jun. 27, 1977;28(3-4):225-7.
Devinsky O, et al. Cerebrospinal fluid levels of neuropeptides, cortisol, and amino acids in patients with epilepsy. Epilepsia. Mar.-Apr. 1993;34(2):255-61.
Deyl Z, et al. Profiling of amino acids in body fluids and tissues by means of liquid chromatography. J Chromatogr. Jun. 20, 1986;379:177-250.
Fariello RG. Action of inhibitory amino acids on acute epileptic foci: an electrographic study. Exp Neurol. Oct. 1979;66(1):55-63.
Ferrie CD, et al. Plasma amino acids in childhood epileptic encephalopathies. Epilepsy Res. Apr. 1999;34(2-3):221-9.
Fürst P, et al. Appraisal of four pre-column derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials. J Chromatogr. Jan. 19, 1990;499:557-69.
Gardner WS, et al. Reverse-phase liquid chromatographic analysis of amino acids after reaction with o-phthalaldehyde. Anal Biochem. Jan. 1, 1980;101(1):61-5.
Georgi G, et al. High-performance liquid chromatographic determination of amino acids in protein hydrolysates and in plasma using automated pre-column derivatization with o-phthaldialdehyde/2-mercaptoethanol. J Chromatogr. Mar. 5, 1993;613(1):35-42.
Gonzalez FJ, et al. Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency. Trends Pharmacol Sci. Oct. 1995;16(10):325-7.
Grove J, et al. Increased gamma-aminobutyric acid (GABA), homocarnosine and beta-alanine in cerebrospinal fluid of patients treated with gamma-vinyl GABA (4-amino-hex-5-enoic acid). Life Sci. May 21, 1981;28(21):2431-9.
Gusel VA, et al. [Effect of GABA-positive substances on the primary and mirror epileptogenic foci in the hippocampus of rats] Farmakol Toksikol. May-Jun. 1986;49(3):96-100.
Haines JL, et al. Altered amino acid levels in multiply affected sibships with seizures. Epilepsia. Nov.-Dec. 1985;26(6):642-8.
Hamberger A, et al. Nico M. van Gelder, the inquisitive neurochemist. Neurochem Res. Nov. 1999;24(11):1321-4.
Higgins JJ, et al. Pyridoxine-responsive hyper-beta-alaninemia associated with Cohen's syndrome. Neurology. Sep. 1994;44(9):1728-32.
Holopainen I, et al. High-affinity uptake of taurine and beta-alanine in primary cultures of rat astrocytes. Neurochem Res. Feb. 1986;11(2):207-15.
Horikoshi T, et al. Taurine and beta-alanine act on both GABA and glycine receptors inXenopus oocyteinjected with mouse brain messenger RNA. Brain Res. Sep. 1988;464(2):97-105.
Hosli E, et al. Cellular localization of the uptake of [3H]taurine and [3H]beta-alanine in cultures of the rat central nervous system. Neuroscience. 1980;5(1):145-52.
Iinuma K, et al. Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid. Eur J Pediatr. Dec. 1988;148(3):267-9.
Jaeken J, et al. Gamma-vinyl GABA, and GABA and beta-alanine transamination. The Lancet. Mar. 31, 1984; 323:737.
Jacobs WA, et al. Stability of o-phthalaldehyde-derived isoindoles. Anal Biochem. Aug. 1, 1986;156(2):334-40.
Jarrett HW, et al. The separation of o-phthalaldehyde derivatives of amino acids by reversed-phase chromatography on octylsilica columns. Anal Biochem. Feb. 15, 1986;153(1):189-98.
Jones BN, et al. o-Phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids. J Chromatogr. Aug. 26, 1983;266:471-82.
Kawamura H, et al. Depression of cerebellar Purkinje cells by microiontophoretic application of GABA and related amino acids. Brain Res. Dec. 1, 1970;24(2):293-304.
Kihara M, et al. Release by electrical stimulation of endogenous glutamate, gamma-aminobutyric acid, and other amino acids from slices of the rat medulla oblongata. J Neurochem. Jan. 1989;52(1):261-7.
Kontro P. Beta-alanine uptake by mouse brain slices. Neuroscience. Jan. 1983;8(1):153-9.
Lahat E, et al. Aminoaciduria resulting from vigabatrin administration in children with epilepsy. Pediatr Neurol. Jul. 1999;21(1):460-3.
Larsson OM, et al. Mutual inhibition kinetic analysis of gamma-aminobutyric acid, taurine, and beta-alanine high-affinity transport into neurons and astrocytes: evidence for similarity between the taurine and beta-alanine carriers in both cell types. J Neurochem. Aug. 1986;47(2):426-32.
Lopez-Colome AM, Taurine receptors in CNS membranes: binding studies. Adv Exp Med Biol. 1981;139:293-310.
Martin DL, et al. High affinity transport of taurine and beta-alanine and low affinity transport of gamma-aminobutyric acid by a single transport system in cultured glioma cells. J Biol Chem. Aug. 10, 1979;254(15):7076-84.
McBride WJ, et al. Contents of several amino acids in the cerebellum, brain stem and cerebrum of the ‘staggerer’, ‘weaver’ and ‘nervous’ neurologically mutant mice. J Neurochem. May 1976;26(5):867-70.
Monaco F, et al. Free amino acids in serum of patients with epilepsy: significant increase in taurine. Epilepsia. Jun. 1975;16(2):245-9.
Monaco
Campbell Allyson J.
Carran John R.
Lyon Angela P.
Weaver Donald F.
Davidson, Davidson & Kappel
Queen's University at Kingston
Wallenhorst Maureen M.
LandOfFree
Diagnostic methods for determining susceptibility to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic methods for determining susceptibility to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic methods for determining susceptibility to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3668860