Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-12-23
1997-01-21
Jones, W. Gary
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 911, 435 912, 435 9121, 435 913, 435 9132, 435 915, 435 9151, 436501, 436 63, 536 221, 536 231, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 78, C12Q 168, C07H 2104
Patent
active
055958699
ABSTRACT:
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.
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Croce Carlo M.
Tsujimoto Yoshihide
Jones W. Gary
Marschel Ardin H.
The Wistar Institute
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