Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1986-07-09
1991-05-14
Wax, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 6, 435 723, 436501, 436538, 436813, 530350, 530387, 530806, 530828, 536 27, C12Q 168, G01N 3353
Patent
active
050155687
ABSTRACT:
The sequence of the protein coding regions of the bcl-2 gene are provided as well as bacterial clones which produce the proteins. Assays are provided for detecting a class of B-cell neoplasms associated with a chromosome translocation between chromosomes 14 and 18. This translocation is involved in the majority of cases of human follicular lymphomas. One assay employs an antibody which is immunoreactive with a human protein which is over-expressed due to the chromosome translocation. Another assay involves measurement of the amount of mRNA which hybridizes to the gene proximal to the translocation break-point.
REFERENCES:
Tsujimoto et al., (Jul. 1986), Proc. Natl. Acad. Sci. (USA), vol. 83, pp. 5214-5218.
Tsujimoto et al., "Clustering of Breakpoints on Chromosome II in Human B-Cell Neoplasms with the t(11;14) Chromosome Translocation", Nature, vol. 315, pp. 340-343 (1985).
Tsujimoto et al., "Involvement of the bcl-2 Gene in Human Follicular Lymphoma", Science, vol. 228, pp. 1440-1443 (1985).
Tsujimoto et al., "The t(14;18) Chromosome Translocations Involved in B-Cell Neoplasms Result from Mistakes in VDJ Joining", Science, vol. 229, pp. 1390-1393, (1985).
Pegoraro et al., "A 14;18 and an 8;14 Chromosome Translocation in a Cell Line Derived from an Acute B-Cell Leukemia", Proc. Natl. Acad. Sci. USA, vol. 81, pp. 7166-7170 (1984).
Tsujimoto et al., "Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation", Science, vol. 226, pp. 1097-1099 (1984).
Michael L. Cleary and Jeffrey Sklar, "Nucleotide Sequence of Chromosomal Breakpoint in Follicular Lymphoma and Demonstration of a Breakpoint in Follicular Lymphoma and Demonstration of a Breakpoint-Cluster Region Near a Transcriptionally Active Locus on Chromosome 18", Proc. Nat'l Acad. Sci. USA, vol. 82, pp. 7439-7443, 11/85.
Croce Carlo A.
Tsujimoto Yoshihide
Marschel Ardin H.
The Wistar Institute
Wax Robert A.
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