Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2008-03-11
2008-03-11
Le, Long V. (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C435S007920, C436S512000, C436S513000, C436S514000, C436S536000
Reexamination Certificate
active
07341839
ABSTRACT:
Diagnostic methods for identifying a test subject who has or is at risk of developing age-related macular degeneration (AMD) or an analogous disease associated with oxidation of DHA-containing lipids are provided. In one aspect, the methods comprise: assaying for the presence of elevated levels of 2-(ω-carboxyethyl) pyrrole (CEP) adducts in a bodily fluid which has been obtained from the test subject. In a preferred embodiment, such methods comprise providing an antibody that is immunospecific for CEP, contacting a bodily fluid from the subject with the anti-CEP antibody, and assaying for the formation of a complex between the antibody and an antigen in the sample. In another aspect, the methods comprise assaying for the presence of elevated levels of an antibody that binds to or is immunospecific for a CEP adduct in the bodily fluid of the test subject. The present invention also relates to CEP protein and peptide adducts, an antibody reactive with a CEP adduct and a diagnostic kit comprising such antibody.
REFERENCES:
patent: 5686250 (1997-11-01), Salomon
Crabb, et al., Abstract 2109-B355, “Oxidative Protein Modification in AMD from Docosahexaenoic Acid” Investigative Ophthalmology and Visual Science, vol. 41, No. 4, Mar. 15, 2000.
Lecomte, et al., “Docosahexaenoic Acid Is A Major n-3-Polyunsaturated Fatty Acid in Bovine Retinal Microvessels” Journal of Neurochemistry, 66, 2160-2167 (1996).
Bernoud-Hubac, et al., “Formation of Highly Reactive y-Ketoaldehydes (Neuroketals) as Products of the Neuroprostane Pathway” The Journal of Biological Chemistry, vol. 276, No. 33, Aug. 17, 2001, pp. 30964-30970.
Crabb John W.
Gu Xiaorong
Hollyfield Joe G.
Salomon Robert G.
Calfee, Halter & Griswold LLP.
Case Western Reserve University
Cheu Jacob
Le Long V.
The Cleveland Clinic Foundation
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