Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-05-23
2006-05-23
Gambel, Phillip (Department: 1644)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C514S021800, C530S350000, C436S501000
Reexamination Certificate
active
07049081
ABSTRACT:
The present invention relates to novel antiproliferative genes. More specifically, isolated nucleic acid molecules are provided encoding the human B-cell translocation genes 2 and 3 (BTG-2 and BTG-3). BTG-2 and BTG-3 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same.
REFERENCES:
patent: 6013469 (2000-01-01), Kunsch et al.
patent: WO96/29401 (1996-09-01), None
Matsuda et al., FEBS Letters, 2001, 497:67-72.
The Merck Manual of Dignosis and Therapy, 1999, Published by Merck Research Laboratories, pp. 978-979.
Attwood, Science 2000, vol. 290, pp. 471-473.
Skolnick et al. Trends in Biotech. 2000, vol. 18, pp. 34-39.
Barton, G.J., “Protein sequence alignment and database scanning,” in: Protein Structure Prediction: A Practical Approach, Sternberg, M.J.E., ed., IRL Press at Oxford University Press, Oxford, U.K., pp. 31-63 (1996).
Bradbury, et al., “Molecular cloning of PC3, a putatively secreted protein whose mRNA is induced by nerve growth factor and depolarization,” Proc. Natl. Acad. Sci. USA, 88:3353-3357 (1991).
Fletcher, et al., “Structure and expression of TIS21, a primary response gene induced by growth factors and tumor promoters,” J. Biol. Chem., 266:14511-14518 (1991).
George, et al., “Current methods in sequence comparison and analysis,” in: Macromolecular Sequencing and Synthesis Selected Methods and Applications, Schlesinger, D.H., ed., Alan R. Liss, Inc., New York, N.Y., pp. 127-149 (1988).
Guehenneux, et al., “Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG Family) involved in the negative control of the cell cycle,” Leukemia, 11:370-375 (Mar. 1997).
Hamil, et al., “Cloning of rat sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: Regulation of TSC-22 gene expression,” Endocrinology, 134:1205-1212 (1994).
Ikematsu, et al., “Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases,” Oncogene, 18(52):7432-7441 (1999).
Marshall, C.J., “Tumor suppressor genes,” Cell, 86:313-326 (1991).
Matsuda, et al., “In search of a function for the TIS21/PC3/BTG1/TOB family,” FEBS Letters, 497:67-72 (2001).
Matsuda, et al., “Tob, a novel protein that interacts with p185 (erbB2), is associated with antiproliferative activity,” Oncogene, 12:705-713 (1996).
Raburn, et al., “Stage-specific expression of B cell translocation in Gene 1 in rat testis,” Endocrinology, 136:5769-5777 (1995).
Rimokh, et al., “A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12) (q24;q22) translocation in a case of B-cell chromic leukemia,” Genes Chromosom. Canc., 3:24-36 (1991).
Rouault, et al., “Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3-prime non-coding regions,” Gene, 129:303-306 (1993).
Rouault, et al., “BTG1, a member of a new family of antiproliferative genes,” EMBO J., 11(4):1663-1670 (1992).
Rouault, et al., “Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway,” Nature Genet., 14:482-486 (1996).
Weinberg, R.A., “Tumor suppressor genes,” Science, 254:1138-1146 (1991).
Chopra Arvind
Kunsch Charles A.
Rosen Craig A.
Gambel Phillip
Human Genome Sciences Inc.
Human Genome Sciences Inc.
Ouspenski Ilia
LandOfFree
Diagnostic methods based on human BTG-2 and BTG-3 polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic methods based on human BTG-2 and BTG-3 polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic methods based on human BTG-2 and BTG-3 polypeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3649386