Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-11-02
1991-10-08
Nucker, Christine
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
530326, 530327, 530387, 530806, 43524027, 435810, 435 792, 436548, 436518, 436808, 935 96, 935110, G07N 3353, C12N 500, G01N 33543
Patent
active
050553968
ABSTRACT:
The present invention describes a monoclonal antibody that is directed against an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Also disclosed is a polypeptide capable of immunologically mimicking an Apo AI/HLD epitope whose expression is substantially unaffected by deamidation. Diagnostic systems and methods for determining the amount of Apo AI in a vascular fluid sample using a disclosed monoclonal antibody and/or a disclosed polypeptide are also described.
REFERENCES:
patent: 4327075 (1982-04-01), Luning
L. K. Curtiss, Immunochemical Heterogeneity of Human Plasma High Density Lipoproteins, vol. 260, No. 5, Mar. 10, 1985, pp. 2982-2993, The Journal of Biological Chemistry.
Curtiss et al., J. Biol. Chem., 263:13779-13785 (1988).
Curtiss Linda K.
Smith Richard S.
Nucker Christine
Scheiner Laurie A.
Scripps Clinic and Research Foundation
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