Diagnostic methods

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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Reexamination Certificate

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08053198

ABSTRACT:
The present invention relates to methods of diagnosing cancerous conditions in a patient, as well as methods of monitoring the progression of a cancerous condition and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

REFERENCES:
patent: 4168146 (1979-09-01), Grubb et al.
patent: 4235601 (1980-11-01), Deutsch et al.
patent: 4366241 (1982-12-01), Tom et al.
patent: 4442204 (1984-04-01), Greenquist et al.
patent: 5208535 (1993-05-01), Nakayama et al.
patent: 5807522 (1998-09-01), Brown et al.
patent: 6110426 (2000-08-01), Shalon et al.
patent: 2003/0113713 (2003-06-01), Glezer et al.
patent: 2003/0207290 (2003-11-01), Kenten et al.
patent: 2004/0022677 (2004-02-01), Wohlstadter et al.
patent: 2004/0189311 (2004-09-01), Glezer et al.
patent: 2005/0052646 (2005-03-01), Wohlstadter et al.
patent: 2005/0142033 (2005-06-01), Glezer et al.
patent: 2006/0205012 (2006-09-01), Debad et al.
patent: WO 99/26067 (1999-05-01), None
patent: WO 2004/058055 (2004-07-01), None
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Swidzinska et al (Pneumonol Alegol Pol, 2004, 72(9-10): abstract).
Tas et al (Melanoma Research, 2006, 16(5): abstract.
Alberts et al. (Molecular Biology of the Cell, 3rd edition, 1994, p. 465).
Greenbaum et al. (Genome Biology, 2003, vol. 4, Issue 9, pp. 117.1-117.8).
Yokoyama et al (Gynecologic Oncology, 2000, 77:413-418).
Kumar et al (Anticancer Research, 2002, 22(3): 1877-1880).
Yokoe et al (Breast Cancer, 2000, 7(3): abstract).
Benoy et al (Clin Breast Cancer, 2002, 2(4):abstract).
Benoy et al (Clin Breast Cancer, 2002, 2(4):311-315).
Climente et al (Clin Transl Oncol., Jun. 2006, 8(6): Abstract).
Chen et al (Gynecologic Oncology, 2004, 630-635).
Zhao et al (Cancer Research, 2009, 69(19): 7696-7703).
Aref S. et al., “Soluble VEGF/sFLt1 Ratio is an Independent Predictor of AML Patient Out Come”,Hematology10 (2):131-134 (2005).
Aung PP et al., “Systematic Search for Gastric Cancer-Specific Genes Based on SAGE Data: Melanoma Inhibitory Activity and Matrix Metalloproteinase-10 are Novel Prognostic Factors in Patients with Gastric Cancer”,Oncogen25:2546-2557 (2006).
Bando H. et al., “Association Between Intratumoral Free and Total VEGF, Soluble VEGFR-1, VEGFR-2 and Prognosis in Breast Cancer”,British Journal of Cancer92:553-561 (2005).
Baron A.T. et al., “Soluble Epidermal Growth Factor Receptor (SEG-FR) and Cancer Antigen 125 (CA125) as Screening and Diagnostic Tests for Epithelial Ovarian Cancer”,Cancer Epidemiology Biomarkers Prevention14(2):306-318 (2005).
Buller R.E. et al., “CA 125 Kinetics: A Cost-Effective Clinical Tool to Evaluate Clinical Trial Outcomes in the 1990s”,American Journal of Obstetrics and Gynecology 174:1241-1254 (1996).
Buys S.S. et al., “Ovarian Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: Findings from the Initial Screen of Randomized Trial”,American Journal of Obstetrics and Gynecology193:1630-1639 (2005).
Caine G.J. et al., “Changes in Plasma Vascular Endothelial Growth Factor, Angiopoietins, and Their Receptors Following Surgery for Breast Cancer”,Cancer Letters248:131-136 (2007).
Chen H. et al., “VEGF, VEGFRs Expressions and Activated STATs in Ovarian Epithelial Carcinoma”,Gynecologic Oncology94(3):630-635 (2004).
Cooper B.C. et al., “Preoperative CA 125 Levels: An Independent Prognostic Factor for Epithelial Ovarian Cancer”,Obstetrics&Gynecology100(1):59-64 (2002).
Dales JP et al., “Prediction of Metastasis Risk (11 Year Follow-Up) Using VEGF-RI, VEGF-R2, Tie-2/Tek and CD105 Expression in Breast Cancer (n=905)”,British Journal of Cancer90(6):1216-1221 (2004).
Debad J.D. et al., “Clinical and Biological Applications of ECL”,Electrogenerated Chemiluminescencepp. 359-396 (2004).
Enjoji M. et al., “Clinical Significance of Serum Levels of Vascular Endothelial Growth Factor and its Receptor in Biliary Disease and Carcinoma”,World Journal of Gastroenterology11(8):1167-1171 (2005).
Gill J.H. et al., “MMP-10 is Overexpressed, Proteolytically Active, and a Potential Target for Therapeutic Intervention in Human Lung Carcinomas”,Neoplasia6(6):777-785 (2004).
Gorelik E. et al., “Multiplexed Immunobead-Based Cytokine Profiling for Early Detection of Ovarian Cancer”,Cancer Epidemiology, Biomarkers&Prevention14(4):981-987 (2005).
Guidi A.J. et al., “Expression of Vascular Permeability Factor (Vascular Endothelial Growth Factor) and its Receptors in Endometrial Carcinoma”,Cancer78(3):454-460 (1996).
Hoar F.J. et al., “Circulating Levels of VEGF-A, VEGF-D and Soluble VEGF-A Receptor (sFlt-1) in Human Breast Cancer”,The International Journal of Biological Markers19(3):229-235 (2004).
Hellstrom I. et al., “Mesothelin Variant 1 is Released from Tumor Cells as a Diagnostic Marker”,Cancer Epidemiology, Biomarkers&Prevention15(5):1014-1020 (2006).
Hsieh F-C et al., “Evaluation of Potential Stat3-Regulated Genes in Human Breast Cancer”,Biochemical and Biophysical Research Communications335(2):292-299 (2005).
Iihan N. et al., “Functional Significance of Vascular Endothelial Growth Factor and its Receptor (Receptor-1) in Various Lung Cancer Types”,Clinical Biochemistry37(9):840-845 (2004).
Inan S. et al., “Immunolocalizations of VEGF, its Receptors Flt-1, KDR and TGF-β's in Epithelial Ovarian Tumors”,Histol Histopathol21(10):1055-1064 (2006).
Jacobs I.J. et al., “Progress and Challenges in Screening for Early Detection of Ovarian Cancer”,Molecular&Cellular Proteomics3(4):355-366 (2004).
Kodama J. et al., “Serum C-Reactive Protein as a Prognostic Factor in Patients with Epithelial Ovarian Cancer”,European Journal of Obstetrics&Gynecology and Reproductive Biology82(1):107-110 (1999).
Kumar H. et al., “Soluble FLT-1 is Detectable in the Sera of Colorectal and Breast Cancer Patients”,Anticancer Research22(3):1877-1880 (2002).
Le Page C. et al., “From Gene Profiling to Diagnostic Markers: IL-18 and FGF-2 Complement CA125 as Serum-Based Markers in Epithelial Ovarian Cancer”,Int. J. Cancer118(7):1750-1758 (2006).
Lokshin A.E. et al., “Circulating IL-8 and Anti-IL-8 Autoantibody in Patients with Ovarian Cancer”,Gynecologic Oncology102(2):244-251 (2006).
Macciò A. et al., “High Serum Levels of Soluble IL-2 Receptor, Cytokines, and C Reactive Protein Correlate with Impairment of T Cell Response in Patients with Advanced Epithelial Ovarian Cancer”,Gynecologic Oncology69(3):248-252 (1998).
Mathew R. et al., “Stromelysin-2 Overexpression in Human Esophageal Squamous Cell Carcinoma: Potential Clinical Implications”,Cancer Detection and Prevention26(3):222-228 (2002).
Matsumoto K. et al., “Prognostic Significance of Plasma Placental Growth Factor Levels in Renal Cell Cancer: An Association with Clinical Characteristics and Vascular Endothelial Growth Factor Levels”,Anticancer Research23(6D):4953-4958 (2003).
McCluggage W.G. et al., “Immunohistochemistry as a Diagnostic Aid in the Evaluation of Ovarian Tumors”,Seminars in Diagnostic Pathology22(1):3-32 (2005).
Meunier-Carpentier S. et al., “Comparison of the Prognosis Indication of VEGFR-1 and VEGFR-2 and Tie2 Receptor Expression in Breast Carcinoma”,International Journal of Oncology26(4):977-984 (2005).
Miyata Y. et al., “Expression of Matrix Metalloproteinase-10 in Renal Cell Carcinoma and its Prognostic Role”,European Urology52(3):791-797 (2007).
Mor G. et al., “Serum Protein Markers for Early Detection of Ovarian Cancer”,PNAS102(21):7677-7682 (2005).
Moradi M.M. et al,. “Serum and Ascitic Fluid Levels of Interleukin-1, Interleukin-6, and Tumor

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