Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1990-08-23
1995-06-27
Scheiner, Toni R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 72, 435 721, 435 79, 435960, 436501, 436 64, 436813, 436815, 436827, G01N 33574, G01N 3353
Patent
active
054279143
ABSTRACT:
A process is disclosed for the determination of the malignant potential of a tumor. The process comprises the steps of determining the amount of BBO in a tumor sample by reacting the BBO in a tumor sample with a BBO-binding lectin or a BBO-specific antibody to form a BBO-lectin or a BBO-specific antibody complex. Then, the amount of BBO-lectin or BBO-antibody complex or of unreacted BBO can be measured.
REFERENCES:
patent: 4334017 (1982-06-01), Plotkin
patent: 4455380 (1984-06-01), Adachi
Pierce, M., et al., J. Biol. Chem., vol. 261, No. 23, Aug. 1986, pp. 10772-10777.
Helle, M., et al., Virchows Archiv A (Pathol. Anat.), vol. 410, 1986, pp. 23-29.
Ollerich, M., J. Clin. Chem. Clin. Biochem., vol. 22, 1984, pp. 895-904.
Warren et al, "Glycopeptide Changes and Malignant Transformation: A Possible Role for Carbohydrate in Malignant Behavior", Biochim. Biophys. Acta. 516, p. 97, 1978.
Santer and Glick, "Partial Structure of a Membrane Glycopeptide from Virus-Transformed Hamster Cells" Biochem. 18, p. 2533, 1979.
Collard et al, "Transfection by Human Oncogenes: Concomitant Induction of Tumorigenicity and Tumor-Associated Membrane Alterations", Int. J. Cancer 35, p. 207, 1985.
Warren et al, "Surface Glycoproteins of Normal and Transformed Cells: A Difference Determined by Sialic Acid and a Growth-Dependent Sialyl Transferase", Proc. Nat. Acad. Sci. USA 69, p. 1838, 1972.
Van Beek et al, "Changed Surface Glycoprotein as a Marker of Malignancy in Human Leukaemic Cells", Nature 253, p. 457, 1975.
Hunt and Wright, "Both Acidic-Type and Neutral-Type Asparaginyl-Oligosaccharides of Host-Cell Glycoproteins are Altered in Rous-Sarcoma-Virus-Transformed Chick-Embryo Fibroblasts", Biochem. J. 229, p. 441, 1985.
Yamashita et al, "Comparative Study of the Oligosaccharides Released from Baby Hamster Kidney Cells and Their Polyoma Transformant by Hydrazinolysis", J. Biol. Chem. 259, p. 10834, 1984.
Pierce and Arango, "Rous Sarcoma Virus-transformed Baby Hamster Kidney Cells Express Higher Levels of Asparagine-linked Tri- and Tetraantennary Glycopeptides Containing [GlcNAc- .alpha. (1,6)Man- .beta. (1,6)Man] and Poly-N-acetyllactosamine Sequences Than Baby Hamster Kidney Cells", J. Biol. Chem. 261, p. 10772, 1986.
Schachter, H., "Biosynthetic controls that Determine the Branching and Microheterogeneity of Protein-bound Oligosaccharides", Biochem. Cell Biol. 64, p. 163, 1985.
Gleeson and Schachter, "Control of Glycoprotein Synthesis", J. Biol. Chem. 258, p. 6162, 1983.
Damjanov, I., "Biology of Disease: Lectin Cytochemistry and Histochemistry", ab. Invest. 57, p.5, 1987.
Debray et al, "Altered Glycosylation of Membrane Glycoproteins in Human Uroepithelial Cell Lines", Int. J. Cancer 37, p. 607, 1986.
Santer et al, "Change in Glycosylation of Membrane Glycoproteins after Tranfection of N1H 3T3 with Human Tumor DNA", Cancer Research 44, p. 3730, 1984.
Limas and Lange, "T-Antigen in Normal and Neoplastic Urothelium", Cancer 58, p. 1236, 1986.
Helle and Krohn, "Reactivity of a Monoclonal Antibody Recognicing an Estrogen Receptor Regulated Glycoprotein in Relation to Lectin Histochemistry in Breast Cancer", Vir. Arch. A 410, p. 23, 1986.
Bocker et al, "Peanut Lectin Histochemistry of 120 Mammary Carcinomas and Its Relation to Tumor Type, Grading, Staging, and Receptor Status", Vir. Arch. A 403, p. 149, 1984.
Walker, R., "Commentary: The Use of Lectins in Histopathology", Histopath. 9, p. 1121, 1985.
Holthofer et al, "Ulex europaeus I Lectin as a Marker for Vascular Endothelium in Human Tissues", Lab. Invest. 47, p. 60, 1982.
Miettinen et al, "Ulex europaeus I Lectin as a Marker for Tumors Derived from Endothelial Cells", Am. J. Clin. Pathol. 79, p. 32, 1983.
Ordonez and Batsakis, "Comparison of Ulex europaeus I Lectin and Gactor VIII-Related Antigen in Vascular Lesions", Arch. Pathol. Lab. Med. 108, p. 129, 1984.
Leathem and Brooks, "Predictive Value of Lectin Binding on Breast-Cancer Recurrence and Survival", The Lancet, May 9, p. 1054, 1987.
Koenderman et al, "Changes in the expression of N-acetylglucosaminyltransferase III, IV, V Associated With the Differentiation of HL-60 Cells", FEBS Lett. 222, p. 42, 1987.
Pierce et al, "Activity of UDP-GLCNAC: .alpha.-Mannoside.beta.(1,6)N-Acetylglucosaminyltransferase (GnT V) in Cultured Cells Using a Synthetic Trisaccharide Acceptor", Biochem. and Biophys. Res. Comm. 146, p. 679, 1987.
Mount Sinai Hospital Corporation
Scheiner Toni R.
LandOfFree
Diagnostic method to screen tumors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Diagnostic method to screen tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic method to screen tumors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-286475