Chemistry: analytical and immunological testing – Peptide – protein or amino acid
Reexamination Certificate
2008-01-22
2008-01-22
Le, Long V. (Department: 1641)
Chemistry: analytical and immunological testing
Peptide, protein or amino acid
C435S007100, C435S975000, C436S089000, C436S518000, C530S300000, C530S387900
Reexamination Certificate
active
07320894
ABSTRACT:
The present invention concerns methods and kits for diagnosing a disease condition characterized by non-physiological levels of hepcidin, comprising obtaining a tissue or fluid sample from a subject; contacting the sample with an antibody or fragment thereof that specifically binds to a polypeptide corresponding to the mid-portion or C terminus of a hepcidin protein, and quantifying the hepcidin level using an assay based on binding of the antibody and the polypeptide; wherein the non-physiological level of hepcidin is indicative of the disease condition. The present invention also concerns diagnostic methods and kits for applications in genetic technological approaches, such as for overexpressing or downregulating hepcidin. The present invention further concerns therapeutic treatment of certain diseases by treatment of subjects with hepcidin and agonists or antagonists of hepcidin.
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Geacintov Cyril E.
Janetzko Alfred
Kulaksiz Hasan
Stremmel Wolfgang
Counts Gary W.
DRG International, Inc.
Fox Rothschild LLP
Le Long V.
Norton Gerard P.
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