Diagnostic method for determining precorneal retention time of o

Details Diagnostic method for determining precorneal retention time of o Diagnostic method for determining precorneal retention time of o

1991-09-13

1994-06-28

Green, Randall L.

Surgery

Truss

Pad

128664, 128898, A61B 500, A61B 600, A61B 1900

Patent

active

053237757

ABSTRACT:
Apparatus and method for measuring ophthalmic formulation retention on the surface of an eye include dissolving a fluorescent macromolecule in an ophthalmic formulation to form a fluorescently labelled formulation; topically administering the fluorescently labelled formulation to an eye, said fluorescently labelled formulation forming a thin film on the eye surface. Apparatus is provided for illuminating the eye to cause fluorescence of the fluorescently labelled formulation as the fluorescently labelled formulation thin film is eliminated from the eye by normal blinking and lacrimation; and for measuring fluorescence from the thin film as a function of time.

REFERENCES:
patent: 4003991 (1977-01-01), Krahn et al.
patent: 4120949 (1978-10-01), Bapatta et al.
patent: 4407792 (1983-10-01), Schoenwald et al.
patent: 4409205 (1983-10-01), Shively
patent: 4412543 (1983-11-01), Vassiliadis et al.
patent: 4474751 (1984-10-01), Haslam et al.
patent: 4540568 (1985-09-01), Trager et al.
patent: 4573778 (1986-03-01), Shapiro
patent: 4594326 (1986-06-01), Wade
patent: 4597965 (1986-07-01), Holly
patent: 4702576 (1987-10-01), Magnante
patent: 4711540 (1987-12-01), Yoshino et al.
patent: 4711541 (1987-12-01), Yoshino et al.
patent: 4744980 (1988-05-01), Holly
patent: 4842401 (1989-06-01), Maurice
patent: 4852987 (1989-08-01), Lohmann
patent: 4863261 (1989-09-01), Flammer
patent: 4883351 (1989-11-01), Weiss
patent: 4883658 (1989-11-01), Holly
patent: 4895159 (1990-01-01), Weiss
patent: 4966773 (1990-10-01), Gressel et al.
patent: 5025785 (1991-06-01), Weiss
patent: 5171526 (1992-12-01), Wong et al.
International Jove Pharmaceutics vol. 61, No. 1, 2, Jun. 11, 1990 Amsterdam investigative Ophthamology vol. 14/12 Dec. 1975 pp. 887-902.
Analytical Biochemistry vol. 130, 1983 U.S. pp. 287-294.
"The Instilled Fluid Dynamics and Surface Chemistry of Polymers in the Preocular Tear Film", Benepeitto, P. A. et al. Investigative Opthalmology p. 887 Dec. 1975.
"Evaluation of Viscous Ophalmic Vehicles Containing Carboner by Slit-Lamp Fluorophotometry in Humans", Ludwig, A et al. International Jo. of Pharmaceutics p. 15 vol. 61 1990.
"The Effect of Viscosity of the Vehicle on the Penetration of Fluorescein into the Human Eye", Adler, C. A. et al. Exptl Eye Res p. 34 vol. 11, 1971.
"The Evaluation of Viscous Ophthalmic Vehicles by Slit Lamp Fluorophotometry in Humans", Ludwig A. et al. Intl. Jo. of Pharaceutics p. 95 vol. 54, 1989.
"Scintgraphic Assesment of an Opthalmic Gelling Vehicle in Man and Rabbit".
Greaves, J. L. et al. Current Eye Research, p. 415 vol. 9 No. 5, 1990.

Affiliated with

Also associated with

Rating

Diagnostic method for determining precorneal retention time of o does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Diagnostic method for determining precorneal retention time of o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Diagnostic method for determining precorneal retention time of o will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2371175