Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-04-16
1988-11-22
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
436503, 436504, 436518, 436548, 436813, 436817, 935110, G01N 3353, G01N 33567, G01N 33543
Patent
active
047865938
ABSTRACT:
It has been determined that nerve growth factor binds to a cell surface protein of human neural crest origin having a molecular weight of about 75,000 daltons. New monoclonal antibodies specifically imunoprecipitate these receptor molecules, and also inhibit binding of the hormone to the receptor. These monoclonal antibodies show significantly higher reactivity with primary and metastatic melanoma cell lines than with melanocytes. The antibodies are used in a diagnostic method for histochemical detection of human neural crest disease.
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Herlyn Meenhard
Koprowski Hilary
Ross Alonzo
Hoffer Florina B.
Warden Robert J.
Wistar Institute of Anatomy and Biology
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