Diagnostic method for a transmissible spongiform...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C424S093700, C424S093710, C424S093720, C424S093730, C424S130100, C424S158100, C424S184100, C424S198100, C436S501000

Reexamination Certificate

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07413865

ABSTRACT:
A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or platelet cell lineages in the sample or an expression product thereof.

REFERENCES:
patent: 6110739 (2000-08-01), Keller et al.
patent: WO 00/42165 (2000-07-01), None
patent: WO 00/65357 (2000-11-01), None
patent: WO 01/19860 (2001-03-01), None
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Miele, et al., “A Novel Erythroid-Specific Marker of Transmissible Spongiform Encephalopathies”,Nature Medicine, 7(3):361-364 (2001).
Otto, et al., “Elevated Levels of Tau-Protein In Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease”,Neuroscience Letters, 225(3):210-212 (1997).
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Schemerr, et al., “Use of Capillary Electrophoresis and Fluroscent Labeled Peptides to Detect the Abnormal Prion Protein In the Blood of Animals that are Infected with a Transmissible Spongiform Encephalopathy”,J. Chromatogr. A., 853(1-2):207-14 (1999).
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