Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2005-11-08
2005-11-08
Swartz, Rodney P (Department: 1645)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C424S093700, C424S093710, C424S093720, C424S093730, C424S130100, C424S158100, C424S184100, C424S198100, C436S501000
Reexamination Certificate
active
06962787
ABSTRACT:
A method is provided for the diagnosis of a transmissible spongiform encephalopathy (TSE) or prion disease in an animal which comprises assaying a sample obtained from said animal to determine the number of hematopoietic cells of the erythroid, megakaryocyte or platelet cell lineages in the sample or an expression product thereof.
REFERENCES:
patent: 6110739 (2000-08-01), Keller et al.
patent: WO 00/42165 (2000-07-01), None
patent: WO 00/65357 (2000-11-01), None
patent: WO 01/19860 (2001-03-01), None
Wang, X., et al Preparation and determination of monoclonal antibodies against the proteins related to erythroid differentiation Jiepou Xuebao, vol. 28, No. 2, pp. 187-192, 1997.
Hochstrasser, et al., “Elevation of Apolipoprotein E in the CSF of cattle affected by BSE”FEBS Letters,vol. 416 (2), pp. 161-163 (1997).
Otto, et al., “Elevated Levels of Tau-Protein in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease”Neuroscience Letters,vol. 225 (3), pp. 210-212 (1997).
Beekes, et al., “Western Blot Mapping of Disease-Specific Amyloid in Various Animal Species and Humans with Transmissible Spongiform Encephalopathies Using A High-Yield Purification Method”Journal of General Virology,vol. 76 pp. 2567-2576 (1995).
Miele et al., “A Novel Erythroid-Specific Marker of Transmissible Sponigiform Encephalopathies”Nature Medicine,vol. 7 (3) pp. 361-364 (2001).
Prusiner, S.B. “Prions.” Proc. Nat'l Acad. Sci. USA. 1998; 95(23):13363-83.
Schmerr, M.J. et al. “Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathy.” J. Chromatogr. A. 1999; 853(1-2): 207-14.
Ikuta, K. et al. “A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells.” Cell. 1990; 62(5): 863-74.
Sperling Biomedical Foundation, “Index to Science Archives,” Internet: http://www.mad-cow.org/00/sci_archive_frame.html (downloaded Feb. 12, 2002).
Clinton Michael
Manson Jean Catherine
Miele Gino
Hale and Dorr LLP
Pickering William Cutler
Roslin Institute (Edinburgh)
Swartz Rodney P
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