Diagnostic markers for ischemia

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S071000, C436S501000, C436S172000, C436S805000, C436S815000

Reexamination Certificate

active

10243566

ABSTRACT:
This invention relates to the diagnosis and monitoring of ischemia, including but not limited to myocardial and cerebral ischemia, by measuring the concentration of molecules that do not originate from the ischemic tissue but whose concentration in the blood and other fluids changes as a consequence of the ischemic state.

REFERENCES:
patent: 4071413 (1978-01-01), Takahashi et al.
patent: 4369250 (1983-01-01), Gindler
patent: 5225329 (1993-07-01), Marks
patent: 5449607 (1995-09-01), Wilton
patent: 5470714 (1995-11-01), Kleinfeld
patent: 5496735 (1996-03-01), Schwertner
patent: 5512429 (1996-04-01), Wilton
patent: 5604105 (1997-02-01), Jackowski
patent: 5977174 (1999-11-01), Bradley et al.
patent: 6210976 (2001-04-01), Sabbadini
patent: 6264960 (2001-07-01), Robins et al.
patent: 6444432 (2002-09-01), Kleinfeld
patent: 6727258 (2004-04-01), Baraldi
patent: 6750030 (2004-06-01), Kleinfeld
patent: 2004/0077017 (2004-04-01), Karlstrom et al.
patent: 1 043 587 (2003-06-01), None
patent: 1270706 (1981-09-01), None
patent: WO91/09310 (1991-06-01), None
patent: WO 93/08276 (1993-04-01), None
patent: WO93/08276 (1993-04-01), None
patent: WO94/06014 (1994-03-01), None
patent: WO98/57171 (1998-12-01), None
Pelsers, et al. “Fatty Acid-Binding Proteins as Plasma Markers of Tissue Injury,”Clinica Chimica Acta, vol. 352, pp. 15-35, 2005.
Supplementary Partial European Search Report completed on Dec. 21, 2004 and issued to a related, foreign application.
Bansal, et al. “Stroke During Pregnancy and Puerperium in Young Females Below the Age of 40 Years as a Result of Cerebral Venous/Venous Sinus Thrombosis,”Japanese Heart Journal, vol. 21, No. 2, pp. 171-183, Mar. 1980.
Ageeva, et al. “Structural and Functional Characteristics of Red Cell Membranes in Patients with Ischemic Stroke and Dyscirculatory Encephalopathy,” Zhumal Nevrologii I Psikhiatrii Imeni SS Korsakova, vol. 94, No. 1, pp. 6-8, 1994. English Abstract.
Imre, et al. “Increased Proportion of Docosahexanoic Acid and High Lipid Peroxidation Capacity in Erythrocytes of Stroke Patients,”Stroke, vol. 25, No. 12, pp. 2416-2420, 1994.
Supplementary European Search Report completed on Aug. 12, 2004 and issued to a related foreign application.
N. Bazán, et al. “Membrane Lipids in the Pathogenesis of Brain Edema: Phospholipids and Arachidonic Acid, the Earliest Membrane Components Changed at the Onset of Ischemia,”Advances in Neurology, vol. 28:Brain Edema, Raven Press, New York, 1980, pp. 197-205.
N. Bazáan, et al. “Effects of Ischemia and Electroconvulsive Shock on Free Fatty Acid Pool in the Brain,”Biochimica et Biophysica Acta, 218, 1970, pp. 1-10.
M. Ikeda, et al. “Polyphosphoinositides as a Probably Source of Brain Free Fatty Acids Accumulated at the Onset of Ischemia,”Journal of Neurochemistry, Raven Press, New York, 1986, pp. 123-132.
V. Kurien, “Serum-Free-Fatty-Acids After Acute Myocardial Infarction and Cerebral Vascular Occlusion,”The Lancet, Jul. 16, 1966, pp. 122-127.
G. Richieri, et al. “Unbound Free Fatty Acid Levels in Human Serum,”Journal of Lipid Research, vol. 36, 1995, pp. 229-240.
G. Richieri, et al., “Interactions of Long-Chain Fatty Acids and Albumin: Determination of Free Fatty Acid Levels Using the Fluorescent Probe ADIFAB,”Biochemistry, vol. 32, 1993, pp. 7574-7580.
G. Richieri, et al. “Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine,”The Journal of Biological Chemistry, vol. 271, No. 19, May 10, 1996, pp. 11291-11300.
G. Richieri, et al. “The Measurement of Free Fatty Acid Concentration with the Fluorescent Probe ADIFAB: A Practical Guide for the Use of the ADIFAB Probe.”Molecular and Cellular Biochemistry, 192: 1999, pp. 87-94.
G. Richieri, et al. “A Fluorescently Labeled Intestinal Fatty Acid Binding Protein,”The Journal of Biological Chemistry, vol. 267, No. 33, Nov. 25, 1992, pp. 23495-23501.
B. Weinberger, et al. “Effects of Perinatal Hypoxia on Serum Unbound Free Fatty Acids and Lung Inflammatory Mediators,”Biology of the Neonate, vol. 79, 2001, pp. 61-66.
Davies, et al. “Perioperative Variability of Binding of Lidocaine, Quinidine, and Propranolol After Cardiac Operations,”Journal of Thoracic and Cardiovascular Surgery, vol. 96, No. 4, pp. 634-641, Oct. 1998.
Ford, et al. “Use of Serum Markers of Myocardial Injury for the Early Diagnosis of Acute Myocardial Infarction,”ACC Current Journal Review, vol. 5, No. 3, pp. 86-89, May/Jun. 1996.
Kleinfeld et al. “Increases in Serum Unbound Free Fatty Acid Levels Following Coronary Angioplasty,”American Journal of Cardiology, vol. 78, No. 12, pp. 1350-1354, Dec. 15, 1996.
Glatz, et al. “Fatty-Acid-Binding Protein as a Plasma Marker for the Estimation of Myocardial Infarct Size in Humans,”BR Heart J, vol. 71, pp. 135-140, 1994.
Patel, et al. “Serum Levels of Unbound Free Fatty Acids I: Normative Data in Term Newborn Infants,”Journal of American College of Nutrition, vol. 16, No. 1, pp. 81-84, 1997.
Peuhkurinen, et al. “Changes in Myocardial Energy Metabolism in Elective Coronary Angioplasty,”Cardiovascular Research, vol. 25, pp. 158-163, 1991.
Richieri, et al. “Equilibrium Constants for the Binding of Fatty Acids with Fatty Acid-Binding Proteins from Adipocyte, Intestine, Heart, and Liver Measured with the Fluorescent Probe ADIFAB,”The Journal of Biological Chemistry, vol. 269, No. 39, pp. 23918-23930, Sep. 30, 1994.
Richieri, et al. “Thermodynamic and Kinetic Properties of Fatty Acid Interactions with Rat Liver Fatty Acid-Binding Protein,”The Journal of Biological Chemistry, vol. 271, No. 49, pp. 31068-31074, Dec. 6, 1996.
Richieri, et al. “Unbound Free Fatty Acid Levels in Human Serum,”Journal of Lipid Research, vol. 36, No. 2, pp. 229-240, Feb. 1995.
Richieri, et al. “A Fluorescently Labeled Intestinal Fatty Acid Binding Protein. Interactions with Fatty Acids and its Use in Monitoring Free Fatty Acids,”The Journal of Biological Chemistry, vol. 267, No. 33, pp. 23495-23501, Nov. 25, 1992.
Richieri, et al. “Kinetics of Fatty Acid Interactions with Fatty Acid Binding Proteins from Adipocyte, Heart, and Intestine,”The Journal of Biological Chemistry, vol. 271, No. 19, pp. 11291-11300, May 10, 1996.
Ruben, et al. “Serum Levels of Unbound Free Fatty Acids II: The Effect of Intralipid Administration in Premature Infants,”Journal of the American College of Nutrition, vol. 16, No. 1, pp. 85-87, 1997.
Samanta, et al. “Possible Physiological Role of Myocardial Fatty Acid Binding Protein in Phospholipid Biosynthesis,”Journal of Lipid Mediators, vol. 1, pp. 243-255, 1989.
Samanta, et a. “Free Radical Scavenging by Myocardial Fatty Acid Binding Protein,”Free Radical Research Communications, vol. 7, No. 2, pp. 73-82, 1989.
She, et al. “The Substrate Specificities of Four Different Lysophospholipases as Determined by a Novel Fluorescence Assay,”Biochem J., vol. 298, pp. 23-29, 1994.
Victor, et al. “Myocardial Tissue Free Fatty Acids,”Journal of Molecular and Cellular Cardiology, vol. 16, No. 8, pp. 709-721, Aug. 1984.
Textbook of Cardiovascular Medicine, Eric J. Topol, Editor; Lippincott-Raven Publishers, Philadelphia, PA, 1998. Chapter 16, Harvey D. White, “Unstable Angina—Ischemic Syndromes.” pp. 365-393.

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